Absence of bacterial resistance to medical-grade manuka honey
Author
Cooper, Rose
Jenkins, L.
Henriques, A.F.M.
Duggan, R.S.
Burton, N.F.
Date
2010Type
Article
Publisher
Springer Verlag
ISSN
0934-9723
Metadata
Show full item recordAbstract
Clinical use of honey in the topical treatment of
wounds has increased in Europe and North America since
licensed wound care products became available in 2004 and
2007, respectively. Honey-resistant bacteria have not been
isolated from wounds, but there is a need to investigate
whether honey has the potential to select for honey
resistance. Two cultures of bacteria from reference collections
(Staphylococcus aureus NCTC 10017 and Pseudomonas
aeruginosa ATCC 27853) and four cultures isolated
from wounds (Escherichia coli, methicillin-resistant S.
aureus (MRSA), Pseudomonas aeruginosa and S. epidermidis)
were exposed to sub-lethal concentrations of manuka
honey in continuous and stepwise training experiments to
determine whether the susceptibility to honey diminished.
Reduced susceptibilities to manuka honey in the test
organisms during long-term stepwise resistance training
were found, but these changes were not permanent and
honey-resistant mutants were not detected. The risk of
bacteria acquiring resistance to honey will be low if high
concentrations are maintained clinically.
Journal/conference proceeding
European Journal of Clinical Microbiology and Infectious Diseases;
Citation
Cooper, R.A., Jenkins, L., Henriques, A.F.M., Duggan, R.S. and Burton, N.F. (2010) 'Absence of bacterial resistance to medical-grade manuka honey', European Journal of Clinical Microbiology & Infectious Diseases, 29(10), pp.1237-1241
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