Absence of bacterial resistance to medical-grade manuka honey
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Clinical use of honey in the topical treatment of wounds has increased in Europe and North America since licensed wound care products became available in 2004 and 2007, respectively. Honey-resistant bacteria have not been isolated from wounds, but there is a need to investigate whether honey has the potential to select for honey resistance. Two cultures of bacteria from reference collections (Staphylococcus aureus NCTC 10017 and Pseudomonas aeruginosa ATCC 27853) and four cultures isolated from wounds (Escherichia coli, methicillin-resistant S. aureus (MRSA), Pseudomonas aeruginosa and S. epidermidis) were exposed to sub-lethal concentrations of manuka honey in continuous and stepwise training experiments to determine whether the susceptibility to honey diminished. Reduced susceptibilities to manuka honey in the test organisms during long-term stepwise resistance training were found, but these changes were not permanent and honey-resistant mutants were not detected. The risk of bacteria acquiring resistance to honey will be low if high concentrations are maintained clinically.
European Journal of Clinical Microbiology and Infectious Diseases;
Cooper, R.A., Jenkins, L., Henriques, A.F.M., Duggan, R.S. and Burton, N.F. (2010) 'Absence of bacterial resistance to medical-grade manuka honey', European Journal of Clinical Microbiology & Infectious Diseases, 29(10), pp.1237-1241
Dynodwr Gwrthrych Digidol (DOI)http://dx.doi.org/10.1007/s10096-010-0992-1
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
Manuka honey treatment of biofilms of Pseudomonas aeruginosa results in the emergence of isolates with increased honey resistance Camplin, A. L.; Maddocks, Sarah (BioMed Central, 2014)Background Medical grade manuka honeys are well known to be efficacious against Pseudomonas aeruginosa being bactericidal and inhibiting the development of biofilms; moreover manuka honey effectively kills P. aeruginosa ...
Antimicrobial activity of Manuka honey against antibiotic resistant strains of the cell wall free bacteria Ureaplasma parvum and Ureaplasma urealyticum Hillitt, K.L.; Jenkins, Rowena; Spiller, O.B.; Beeton, Michael L. (Wiley, 2016-12-19)The susceptibility of the cell-wall free bacterial pathogens Ureaplasma spp. to Manuka honey was examined. The minimum inhibitory concentration (MIC) of Manuka honey for four Ureaplasma urealyticum and four Ureaplasma ...
Cooper, Rose; Molan, P.C.; Harding, K.G. (Wiley, 2002)Aims: To determine the sensitivity to honey of Gram-positive cocci of clinical significance in wounds and demonstrate that inhibition is not exclusively due to osmotic effects. Methods and Results: Eighteen strains of ...