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Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression

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Author
Kelly, Claire
Precious, Sophie
Scherf, Caroline
Penketh, Richard
Amso, Nazar
Battersby, Alysia
Allen, Nicholas
Dunnett, Stephen
Rosser, Anne
Date
2009
Type
Article
Publisher
Nature Publishing Group
ISSN
1548-7091
Metadata
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Abstract
Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell–derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.
Journal/conference proceeding
Nature Methods;
Citation
Kelly, C.M., Precious, S.V., Scherf, C., Penketh, R., Amso, N.N., Battersby, A., Allen, N.D., Dunnett, S.B. and Rosser, A.E. (2009) 'Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression', Nature methods, 6(4), pp.271-273
URI
http://hdl.handle.net/10369/5307
DOI
http://dx.doi.org/10.1038/nmeth.1308
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