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Synergy between oxacillin and manuka honey sensitizes methicillin-resistant Staphylococcus aureus to oxacillin

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Author
Jenkins, Rowena
Cooper, Rose
Date
2012
Type
Article
Publisher
Oxford University Press
ISSN
0305-7453
Metadata
Show full item record
Abstract
OBJECTIVES: Honey is an ancient wound remedy that has recently been introduced into modern clinical practice in developed countries. Manuka honey inhibits growth of methicillin-resistant Staphylococcus aureus (MRSA) by preventing cell division. In Gram-negative bacteria a synergistic interaction between honey and antibiotics has been suggested. We aimed to determine the effect of manuka honey on oxacillin resistance in MRSA. METHODS: Inhibition of MRSA by manuka honey and oxacillin separately and in combination was tested by disc diffusion, Etest strips, serial broth dilution, chequerboards and growth curves. RESULTS: Manuka honey and oxacillin interacted synergistically to inhibit MRSA. Manuka honey reversed oxacillin resistance in MRSA, and down-regulation of mecR1 was found in cells treated with manuka honey. CONCLUSIONS: Microarray analysis showed that exposure of MRSA to inhibitory concentrations of manuka honey resulted in down-regulation of mecR1. Here we demonstrated that subinhibitory concentrations of honey in combination with oxacillin restored oxacillin susceptibility to MRSA. Other honey and antibiotic combinations must now be evaluated.
Journal/conference proceeding
Journal of Antimicrobial Chemotherapy;
Citation
Jenkins, R.E. and Cooper, R. (2012) 'Synergy between oxacillin and manuka honey sensitizes methicillin-resistant Staphylococcus aureus to oxacillin', Journal of Antimicrobial Chemotherapy, 67(6), pp.1405-1407.
URI
http://hdl.handle.net/10369/5313
DOI
http://dx.doi.org/10.1093/jac/dks071
Collections
  • Un-themed [116]

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