Synergy between oxacillin and manuka honey sensitizes methicillin-resistant Staphylococcus aureus to oxacillin
Oxford University Press
MetadataDangos cofnod eitem llawn
OBJECTIVES: Honey is an ancient wound remedy that has recently been introduced into modern clinical practice in developed countries. Manuka honey inhibits growth of methicillin-resistant Staphylococcus aureus (MRSA) by preventing cell division. In Gram-negative bacteria a synergistic interaction between honey and antibiotics has been suggested. We aimed to determine the effect of manuka honey on oxacillin resistance in MRSA. METHODS: Inhibition of MRSA by manuka honey and oxacillin separately and in combination was tested by disc diffusion, Etest strips, serial broth dilution, chequerboards and growth curves. RESULTS: Manuka honey and oxacillin interacted synergistically to inhibit MRSA. Manuka honey reversed oxacillin resistance in MRSA, and down-regulation of mecR1 was found in cells treated with manuka honey. CONCLUSIONS: Microarray analysis showed that exposure of MRSA to inhibitory concentrations of manuka honey resulted in down-regulation of mecR1. Here we demonstrated that subinhibitory concentrations of honey in combination with oxacillin restored oxacillin susceptibility to MRSA. Other honey and antibiotic combinations must now be evaluated.
Journal of Antimicrobial Chemotherapy;
Jenkins, R.E. and Cooper, R. (2012) 'Synergy between oxacillin and manuka honey sensitizes methicillin-resistant Staphylococcus aureus to oxacillin', Journal of Antimicrobial Chemotherapy, 67(6), pp.1405-1407.
Dynodwr Gwrthrych Digidol (DOI)http://dx.doi.org/10.1093/jac/dks071
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Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
Henriques, Ana (University of Wales, 2006)Honey is an old remedy recently rediscovered as a possible alternative to modern antibiotics in wound management but its mode of action is not fully understood. The antibacterial activity of honey can be divided into ...
Roberts, Aled Edward Lloyd (Cardiff Metropolitan University, 2014)Although manuka honey has been shown to inhibit Pseudomonas aeruginosa, an opportunistic pathogen implicated in cutaneous wound infections, the mechanisms of action are not yet defined. The purpose of this study, therefore, ...
Al-Maaini, Rahma Ali Saleh (University of Wales, 2012)Honey has been shown to have therapeutic properties, which include immunomodulatory and antibacterial activity in vitro and anti-inflammatory, antipyretic and wound healing properties in vivo. A complex mix of factors ...