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dc.contributor.authorJenkins, Rowena
dc.contributor.authorCooper, Rose
dc.date.accessioned2014-02-11T16:43:24Z
dc.date.available2014-02-11T16:43:24Z
dc.date.issued2012
dc.identifier.citationJenkins, R.E. and Cooper, R. (2012) 'Synergy between oxacillin and manuka honey sensitizes methicillin-resistant Staphylococcus aureus to oxacillin', Journal of Antimicrobial Chemotherapy, 67(6), pp.1405-1407.en_US
dc.identifier.issn0305-7453
dc.identifier.urihttp://hdl.handle.net/10369/5313
dc.description.abstractOBJECTIVES: Honey is an ancient wound remedy that has recently been introduced into modern clinical practice in developed countries. Manuka honey inhibits growth of methicillin-resistant Staphylococcus aureus (MRSA) by preventing cell division. In Gram-negative bacteria a synergistic interaction between honey and antibiotics has been suggested. We aimed to determine the effect of manuka honey on oxacillin resistance in MRSA. METHODS: Inhibition of MRSA by manuka honey and oxacillin separately and in combination was tested by disc diffusion, Etest strips, serial broth dilution, chequerboards and growth curves. RESULTS: Manuka honey and oxacillin interacted synergistically to inhibit MRSA. Manuka honey reversed oxacillin resistance in MRSA, and down-regulation of mecR1 was found in cells treated with manuka honey. CONCLUSIONS: Microarray analysis showed that exposure of MRSA to inhibitory concentrations of manuka honey resulted in down-regulation of mecR1. Here we demonstrated that subinhibitory concentrations of honey in combination with oxacillin restored oxacillin susceptibility to MRSA. Other honey and antibiotic combinations must now be evaluated.en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofseriesJournal of Antimicrobial Chemotherapy;
dc.subjectMRSAen_US
dc.subjectMecR1en_US
dc.subjecthoneyen_US
dc.titleSynergy between oxacillin and manuka honey sensitizes methicillin-resistant Staphylococcus aureus to oxacillinen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1093/jac/dks071


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