Analysis and collation of an anonymised dataset, exploring the relationship between large artery stiffness and bone mineral density.
Cardiff Metropolitan University
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Background- Large artery stiffness and osteoporosis due to low bone mineral density are prevalent mostly amongst the elderly and both increase independently with the aging process. However some studies have demonstrated that both have mechanisms that could possibly cause an inverse relationship between PWV and BMD. This is therefore needed to be assessed in order to understand the causes and mechanisms that could be responsible for the inverse relationship. This is therefore a possible way of reducing the associated diseases of both large artery stiffness and low bone mineral density in the future. Methods and results - The analysis and collation of the annonymised dataset was carried out through collection of data from the Heath Hospital, Cardiff s Heart Research Centre of Wales, which took a period of 5 days to collate the haemodynamic and bone mineral density data. The results demonstrated a statistically inverse relationship between bone mineral density and pulse wave velocity (r = -0.26, p = 0.05). Age was significantly higher in the osteoporotic group (68.7± 8.1) (years), P<0.05), whereas BMD was significantly lower in the osteoporotic group (- 3.2±0.9) (g/cm2) (P<0.05). C-F PWV and adjusted C-F PWV was significantly higher in both the osteopenic and osteoporotic groups compared to the normal group.( PWV C-F (m/s); Normal bone mineral density : 9.0 ± 2.2 (years), Osteopenic: 9.9 ± 3.1 (years), Osteoporotic, 10.5 ± 3.4 (years)), (Adjusted PWV C-F (m/s); Normal bone mineral density : 9.2 ± 1.6 (years), Osteopenic: 10.1 ± 2.3 (years), Osteoporotic, 10.3 ±.3.2 (years)). Conclusion - Bone mineral density measured by CT scans and large artery stiffness measured by PWV demonstrated a significant inverse relationship. To conclude, within this study it has been proven that the inverse relationship between BMD and pulse wave velocity is independent of all the factors apart from age within this study and demonstrated a significant association. However when the participants were split into groups of normal, osteopenic and osteoporotic, age was adjusted for and the significant difference between normal, osteopenic and osteoporotic groups were observed. This illustrates the arterial stiffness was independent of age was independently increased as bone mineral density decreases, and therefore in preventing the decrease of BMD or the increased risk of osteoporosis, could prove beneficial in the arterial aging process, and reduce the risk of arterial stiffness.
BSc (Hons) Sports Biomedicine and Nutrition
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