The relationship between waist circumference and vascular haemodynamics (such as arterial a stiffness and blood pressure) post glucose ingestion
Cardiff Metropolitan University
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Purpose: The present study was set out to investigate the impact of acute hyperglycaemia on endothelialfunction and haemodynamic parameters in 20 healthy young adults, free from disease, in relation to waist circumference. Methods: applanation tonometry of the radial artery was used to assess pulse wave analysis, of which arterial stiffness (Alx %), Peripheral Pulse Pressure (pPP), Peripheral Mean Arterial Pressure (pMAP), Central Pulse Pressure (cPP), was assessed by analyzing peripheral and central waveforms. These waveforms, using applanation tonometry and pulse wave analysis was used to measure all haemodynamic variables, pre and post glucose ingestion. Participants all underwent anthropometric tests to determine height, weight, waist circumference and BMI using conventional methods such as oscillometric devices and scales. Blood pressure was also recorded using a semi automated oscillometric device Omron, digital Automatic Blood Pressure Monitor, UK pre and post glucose ingestion. The results illustrated that a glucose load (75grams of glucose from a commercially available soft drink, 500ml) decreased Alx from pre glucose load 7 ± 8 Vs 4 ± 7 post glucose load. However this difference did not reach statistical significance (p = 0.158). Glucose ingestion, pre and post showed no significant association between heart rate (P= 0.403), peripheral pulse pressure (P= 0.118) and central pulse pressure (P=0.171). However a significant relation was seen between peripheral mean arterial pressure, pre glucose load 87 ± 5.1 Vs 82 ± 7 (P=<0.001) post glucose load. Conclusion: the results within this study support the present literature showing that an acute glucose load decreases Alx by the release of insulin and NO synthesis. An increase waist circumference leads to an increase in insulin resistance and endothelial dysfunction. Haemodynamic parameters are vastly affected by multiple factors therefore the causes of arterial stiffness are largely debatable shown by controversial evidence within the literature.
BSc (Hons) Sports Biomedicine and Nutrition
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