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dc.contributor.authorMcEniery, Carmel
dc.contributor.authorMcDonnell, Barry
dc.contributor.authorMunnery, Margaret
dc.contributor.authorWallace, Sharon
dc.contributor.authorRowe, Chloe
dc.contributor.authorCockcroft, John R.
dc.contributor.authorWilkinson, Ian
dc.date.accessioned2014-03-12T12:28:15Z
dc.date.available2014-03-12T12:28:15Z
dc.date.issued2008
dc.identifier.citationMcEniery, C.M., Yasmin, McDonnell, B., Munnery, M., Wallace, S.M., Rowe, C.V., Cockcroft, J.R., Wilkinson, I.B., Anglo-Cardiff Collaborative Trial Investigators & on Behalf of the Anglo-Cardiff Collaborative Trial Investigators 2008, "Central Pressure: Variability and Impact of Cardiovascular Risk Factors: The Anglo-Cardiff Collaborative Trial II", Hypertension, vol. 51, no. 6, pp. 1476-1482.en_GB
dc.identifier.issn0194-911X
dc.identifier.urihttp://hdl.handle.net/10369/5448
dc.descriptionPublished by American Heart Association in Hypertension: http://hyper.ahajournals.org/en_US
dc.description.abstractPulse pressure varies throughout the arterial tree, resulting in a gradient between central and peripheral pressure. Factors such as age, heart rate, and height influence this gradient. However, the relative impact of cardiovascular risk factors and atheromatous disease on central pressure and the normal variation in central pressure in healthy individuals are unclear. Seated peripheral (brachial) and central (aortic) blood pressures were assessed, and the ratio between aortic and brachial pulse pressure (pulse pressure ratio, ie, 1/amplification) was calculated in healthy individuals, diabetic subjects, patients with cardiovascular disease, and in individuals with only 1 of the following: hypertension, hypercholesterolemia, or smoking. The age range was 18 to 101 years, and data from 10 613 individuals were analyzed. Compared with healthy individuals, pulse pressure ratio was significantly increased (ie, central systolic pressure was relatively higher) in individuals with risk factors or disease (P<0.01 for all of the comparisons). Although aging was associated with an increased pulse pressure ratio, there was still an average±SD difference between brachial and aortic systolic pressure of 11±4 and 8±3 mm Hg for men and women aged >80 years, respectively. Finally, stratifying individuals by brachial pressure revealed considerable overlap in aortic pressure, such that >70% of individuals with high-normal brachial pressure had similar aortic pressures as those with stage 1 hypertension. These data demonstrate that cardiovascular risk factors affect the pulse pressure ratio, and that central pressure cannot be reliably inferred from peripheral pressure. However, assessment of central pressure may improve the identification and management of patients with elevated cardiovascular risk.en_US
dc.language.isoenen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.ispartofseriesHypertension;
dc.subjectcentral pressureen_US
dc.subjectpulse pressure ratioen_US
dc.subjectbrachial pressureen_US
dc.subjectcardiovascular risk factorsen_US
dc.subjecthypertensionen_US
dc.subjectpulse pressure amplificationen_US
dc.titleCentral Pressure: Variability and Impact of Cardiovascular Risk Factors: The Anglo-Cardiff Collaborative Trial IIen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1161/HYPERTENSIONAHA.107.105445


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