The Impact of Cardiovascular Risk Factors on Aortic Stiffness and Wave Reflections Depends on Age

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Author
McEniery, Carmel
Maki-Petaja, Kaisa
McDonnell, Barry
Munnery, Margaret
Hickson, Stacey
Franklin, Stanley
Cockcroft, John R.
Wilkinson, Ian
Date
2010Type
Article
Publisher
American Heart Association
ISSN
0194-911X
Metadata
Show full item recordAbstract
Ageing exerts differential effects on arterial stiffness and wave reflections. However, the impact of
cardiovascular risk factors on arterial stiffness and wave reflections and, particularly, how such effects are influenced
by ageing has not been assessed within a single large population, covering a sufficiently wide age range. Therefore, we
determined the extent to which age alters the impact of traditional cardiovascular risk factors on arterial stiffness and
wave reflections. Aortic stiffness and wave reflections were assessed in 4421 individuals (age range 18 to 92 years).
When treated as continuous variables, clinic systolic, diastolic, and pulse pressures and glucose levels were
independently associated with stiffness, and, with the exception of diastolic pressure, these associations were more
marked in older individuals. In contrast, clinic systolic and diastolic pressures and smoking were independently
associated with wave reflections, with stronger associations observed in younger individuals. The impact of traditional
cardiovascular risk factors on arterial stiffness and wave reflections is strongly dependent on age and is largely driven
by blood pressure. Additional studies are required to assess the impact of these arterial measures on cardiovascular
outcome within a single population.
Journal/conference proceeding
Hypertension;
Citation
McEniery, C.M., Yasmin, Maki-Petaja, K.M., McDonnell, B.J., Munnery, M., Hickson, S.S., Franklin, S.S., Cockcroft, J.R. and Wilkinson, I.B. (2010) 'The Impact of Cardiovascular Risk Factors on Aortic Stiffness and Wave Reflections Depends on Age', Hypertension, 56(4), pp.591-597.
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Published by the American Heart Association in Hypertension: http://hyper.ahajournals.org/
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