The Impact of Cardiovascular Risk Factors on Aortic Stiffness and Wave Reflections Depends on Age
Cockcroft, John R.
American Heart Association
MetadataShow full item record
Ageing exerts differential effects on arterial stiffness and wave reflections. However, the impact of cardiovascular risk factors on arterial stiffness and wave reflections and, particularly, how such effects are influenced by ageing has not been assessed within a single large population, covering a sufficiently wide age range. Therefore, we determined the extent to which age alters the impact of traditional cardiovascular risk factors on arterial stiffness and wave reflections. Aortic stiffness and wave reflections were assessed in 4421 individuals (age range 18 to 92 years). When treated as continuous variables, clinic systolic, diastolic, and pulse pressures and glucose levels were independently associated with stiffness, and, with the exception of diastolic pressure, these associations were more marked in older individuals. In contrast, clinic systolic and diastolic pressures and smoking were independently associated with wave reflections, with stronger associations observed in younger individuals. The impact of traditional cardiovascular risk factors on arterial stiffness and wave reflections is strongly dependent on age and is largely driven by blood pressure. Additional studies are required to assess the impact of these arterial measures on cardiovascular outcome within a single population.
McEniery, C.M., Yasmin, Maki-Petaja, K.M., McDonnell, B.J., Munnery, M., Hickson, S.S., Franklin, S.S., Cockcroft, J.R. and Wilkinson, I.B. (2010) 'The Impact of Cardiovascular Risk Factors on Aortic Stiffness and Wave Reflections Depends on Age', Hypertension, 56(4), pp.591-597.
Published by the American Heart Association in Hypertension: http://hyper.ahajournals.org/
Showing items related by title, author, subject and abstract.
The relationship between alcohol consumption and arterial stiffness within a young male population Waters, David (Cardiff Metropolitan University, 2014)Aim: Moderate alcohol consumption has been suggested to protect against heart disease. Heavy drinking, and binge drinking has been considered to have a detrimental effect upon cardiovascular health. Arterial stiffness ...
Evaluation of cardiovascular risk-lowering health benefits accruing from laboratory-based, community-based and exercise-referral exercise programmes Webb, Richard; Thompson, J.E.S.; Ruffino, José; Davies, Nia; Watkeys, Laura; Hooper, S.; Jones, Paul M.; Walters, Gareth; Clayton, Debbie; Morris, Keith; Llewellyn, D.H.; Ward, M.; Wyatt-Williams, J.; McDonnell, Barry (British Medical Journal, 2016-03-01)Background To evaluate the ability of community-based exercise programmes to facilitate public participation in exercise and hence improved cardiovascular health, we assessed the respective impacts of: a continuously ...
Influence of the Central to Peripheral Arterial Stiffness Gradient on the Timing and Amplitude of Wave Reflections Hickson, Stacey S; Nichols, Wilmer W; Yasmin; McDonnell, Barry J; Cockcroft, John R; Wilkinson, Ian B; McEniery, Carmel M (Nature Publishing Group, 2016-10-01)In individuals with compliant aortas, peripheral muscular artery stiffness exceeds central elastic artery stiffness. With ageing, central stiffness increases, with little change in peripheral stiffness, resulting in a ...