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dc.contributor.authorMorris, Keith
dc.contributor.authorTonks, Amanda J.
dc.contributor.authorJones, Ken
dc.contributor.authorAhluwalia, Maninder
dc.contributor.authorThomas, Andrew
dc.contributor.authorTonks, Alex
dc.contributor.authorJackson, S.K.
dc.date.accessioned2014-03-12T16:32:10Z
dc.date.available2014-03-12T16:32:10Z
dc.date.issued2008
dc.identifier.citationMorris, R.H.K., Tonks, A.J., Jones, K.P., Ahluwalia, M.K., Thomas, A.W., Tonks, A. and Jackson, S.K. (2008) 'DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB', Biochemical and Biophysical Research Communications, 370(1), pp.174-178.en_US
dc.identifier.issn0006-291X
dc.identifier.urihttp://hdl.handle.net/10369/5453
dc.identifier.urihttp://dx.doi.org/10.1016/j.bbrc.2008.03.052en_GB
dc.descriptionThe final published version is available at: http://dx.doi.org/10.1016/j.bbrc.2008.03.052en_US
dc.description.abstractThe major phospholipid in pulmonary surfactant dipalmitoyl phosphatidylcholine (DPPC) has been shown to modulate inflammatory responses. Using human monocytes, this study demonstrates that DPPC significantly increased PGE2 (P < 0.05) production by 2.5-fold when compared to untreated monocyte controls. Mechanistically, this effect was concomitant with an increase in COX-2 expression which was abrogated in the presence of a COX-2 inhibitor. The regulation of COX-2 expression was independent of NF-κB activity. Further, DPPC increased the phosphorylation of the cyclic AMP response element binding protein (CREB; an important nuclear transcription factor important in regulating COX-2 expression). In addition, we also show that changing the fatty acid groups of PC (e.g. using l-α-phosphatidylcholine β-arachidonoyl-γ-palmitoyl (PAPC)) has a profound effect on the regulation of COX-2 expression and CREB activation. This study provides new evidence for the anti-inflammatory activity of DPPC and that this activity is at least in part mediated via CREB activation of COX-2
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesBiochemical and Biophysical Research Communications
dc.subjectpulmonary surfactanten_US
dc.subjectinflammationen_US
dc.subjectDPPCen_US
dc.subjectCOX-2en_US
dc.subjectCREBen_US
dc.titleDPPC regulates COX-2 expression in monocytes via phosphorylation of CREBen_US
dc.typeArticleen_US


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