Blood and urinary levels of 2,3 -Butanediol and 1,3 - Propanediol by gas chromatography-mass spectrometry in lactose tolerant and lactose intolerant populations.
Smith, Peter J.
Cardiff Metropolitan University
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Lactase deficiency is a relatively rare complaint in white Caucasians; a single autosomal dominant gene governs lactase persistence, yet worldwide lactase deficiency is normal in adult populations. The symptoms suffered by lactose intolerant individuals is generally seen as been diarrhoea and irritable bowel. The symptoms seen in the lactose intolerance clinic in Llandough Hospital include in addition, headache, muscle pain, joint pain, palpitation and fatigue. The symptoms exhibited by lactose intolerant individuals in Llandough have led Matthews et al (2000) to propose that a toxic process causes lactose intolerance. The proposed source of toxin or toxins, are products of bacterial fermentation. The generally accepted mechanism for lactose intolerance is based on the physical effect of undigested lactose in the gut, especially the osmotic effect, and the generation of gas by colonic fermentation of unabsorbed lactose. The aim of this study was to determine if two bacterial fermentation products, 2,3- butanediol and 1,3-propanediol where produced in excess in lactose intolerant patients. To this end blood and urine was obtained from lactose intolerant subjects post lactose intolerance test, and compared with a lactose tolerant group. To assay 2,3-butanediol and 1,3-propanediol a method was developed using gas chromatography-mass spectrometry. Results obtained showed no significant difference in the levels of these compounds in the lactose intolerant and lactose tolerant groups.
MSc Biomedical Science
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