Maternal cardiac twist pre-pregnancy: Potential as a novel marker of pre-eclampsia
Meah, Victoria L.
Cockcroft, John R.
Stöhr, Eric J.
Cambridge University Press
MetadataShow full item record
Healthy pregnancy is characterised by progressive physiological adaptation of the maternal cardiovascular (CV) system that facilitates optimal fetal development. The adaptations that constitute a healthy or normal progression are not always evident, and, in particular, CV adaptation to pregnancy is highly individualised. Some women develop pregnancy-related CV dysfunction such as pre-eclampsia (PE). Typically, PE is diagnosed by the development of hypertension and proteinuria after 20 weeks of pregnancy and is the leading cause of maternal and perinatal mortality and morbidity. Despite continued efforts to improve the understanding of the aetiology, pathophysiology and subsequently treatment for the disease, CV changes in PE are not well understood. PE before 34 weeks (early onset PE) is believed to differ in pathogenesis from late onset PE (>34 weeks) and can be characterised by a haemodynamic profile of increased systemic vascular resistance (SVR) and lower cardiac output (CO). Early onset PE is more often associated with uteroplacental insufficiency and significant adverse maternal and perinatal outcomes. In contrast, late onset PE (>34 weeks) involves an increased CO and lower SVR and is less likely to be associated with uteroplacental insufficiency and adverse perinatal outcomes. It is not known if PE develops secondary to the CV maladaptation in pregnancy or if a preexisting CV dysfunction predisposes some women to develop PE. Screening, diagnosis and disease management would be vastly improved if more were known about the onset of the maladaptive process associated with PE. To date, a combination of maternal factors including medical history, body mass index, age, parity and blood pressure (BP) have been used to predict the development of PE. In the first trimester, arterial stiffness is significantly increased in women who develop PE. Current hypotheses speculate that CV dysfunction is evident very early in pregnancy in PE and precedes the clinical manifestation at a later stage but whether CV dysfunction is present before pregnancy remains to be elucidated.
Fetal and Maternal Medicine Review;
Meah, V.L., Cockcroft, J.R. and Stöhr, E.J., (2013) 'Maternal cardiac twist pre-pregnancy: potential as a novel marker of pre-eclampsia', Fetal and Maternal Medicine Review, 24(04), pp.289-295.
This article was published in Fetal and Maternal Medicine Review on 13 December 2013 (online), available at http://dx.doi.org/10.1017/S0965539513000156
- Sport Research Groups 
Showing items related by title, author, subject and abstract.
Outcomes of pregnancies diagnosed with Klinefelter syndrome: the possible influence of health professionals Marteau, T.M.; Nippert, I.; Hall, S.; Limbert, Caroline; Reid, M.; Bobrow, M.; Cameron, A.; Cornel, M.; van Diem, M.; Eiben, B.; García‐Miñaur, S.; Goujard, J.; Kirwan, D.; McIntosh, K.; Soothill, P. (Wiley, 2001-07-01)Objective To describe the association between the outcomes of pregnancies diagnosed with Klinefelter syndrome (KS) and the speciality of the health professional providing pre- and post-diagnostic counselling. Met ...
Physical activity behaviour pre-, during and post pregnancy and its relationship with psychological well being Aitken, Gemma (University of Wales Institute Cardiff, 2010)Many women experience changes of mood and a reduction in physical activity levels. The purpose of this study was to discover the impact physical activity levels have on psychological well being between the three months ...
Torta, Ilaria (Cardiff Metropolitan University, 2007)Rubella virus (RV), is a positive-strand RNA enveloped virus and the only member of the genus Rubivirus in the family Togaviridae. RV infection generally causes a mild disease when acquired post-natally. However, when the ...