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Maternal cardiac twist pre-pregnancy: Potential as a novel marker of pre-eclampsia

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Author
Meah, Victoria L.
Cockcroft, John R.
Stöhr, Eric J.
Date
2013
Type
Article
Publisher
Cambridge University Press
ISSN
0965-5395
Metadata
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Abstract
Healthy pregnancy is characterised by progressive physiological adaptation of the maternal cardiovascular (CV) system that facilitates optimal fetal development. The adaptations that constitute a healthy or normal progression are not always evident, and, in particular, CV adaptation to pregnancy is highly individualised. Some women develop pregnancy-related CV dysfunction such as pre-eclampsia (PE). Typically, PE is diagnosed by the development of hypertension and proteinuria after 20 weeks of pregnancy and is the leading cause of maternal and perinatal mortality and morbidity. Despite continued efforts to improve the understanding of the aetiology, pathophysiology and subsequently treatment for the disease, CV changes in PE are not well understood. PE before 34 weeks (early onset PE) is believed to differ in pathogenesis from late onset PE (>34 weeks) and can be characterised by a haemodynamic profile of increased systemic vascular resistance (SVR) and lower cardiac output (CO). Early onset PE is more often associated with uteroplacental insufficiency and significant adverse maternal and perinatal outcomes. In contrast, late onset PE (>34 weeks) involves an increased CO and lower SVR and is less likely to be associated with uteroplacental insufficiency and adverse perinatal outcomes. It is not known if PE develops secondary to the CV maladaptation in pregnancy or if a preexisting CV dysfunction predisposes some women to develop PE. Screening, diagnosis and disease management would be vastly improved if more were known about the onset of the maladaptive process associated with PE. To date, a combination of maternal factors including medical history, body mass index, age, parity and blood pressure (BP) have been used to predict the development of PE. In the first trimester, arterial stiffness is significantly increased in women who develop PE. Current hypotheses speculate that CV dysfunction is evident very early in pregnancy in PE and precedes the clinical manifestation at a later stage but whether CV dysfunction is present before pregnancy remains to be elucidated.
Journal/conference proceeding
Fetal and Maternal Medicine Review;
Citation
Meah, V.L., Cockcroft, J.R. and Stöhr, E.J., (2013) 'Maternal cardiac twist pre-pregnancy: potential as a novel marker of pre-eclampsia', Fetal and Maternal Medicine Review, 24(04), pp.289-295.
URI
http://hdl.handle.net/10369/5650
DOI
http://dx.doi.org/10.1017/S0965539513000156
Description
This article was published in Fetal and Maternal Medicine Review on 13 December 2013 (online), available at http://dx.doi.org/10.1017/S0965539513000156
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