Inhalation challenge in pigeon breeder's disease: BAL fluid changes after 6 hours
European Respiratory Society
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The purpose of this study was to determine the cellular events occurring 6 h after bronchial inhalation challenge, in a group of pigeon breeders. Twelve subjects agreed to undergo challenge, either with nebulized pigeon serum (Ps) (n = 10), or with saline (n = 2). The development of characteristic symptoms was used to detect a positive response in combination with monitoring tests (white blood cell count (WBC), body temperature, and spirometry). An initial bronchoalveolar lavage (BAL) was performed before inhalation challenge, and a further BAL on the previously spared right middle lobe subsegment or lingula 6 h after challenge. Paired bronchoalveolar lavage fluid (BALF) samples were analysed for urea, albumin, total and differential WBC, interleukin-1 and interleukin-2. There was a significant increase in total cells, lymphocytes, T-lymphocytes, and neutrophils; numbers.ml-1 of BALF in responders. A monitoring score reflecting severity of patient response correlated with an increase in all cell types (p < 0.05). In conclusion, responders developed both a BALF lymphocytic and neutrophilic "alveolitis" following inhalation challenge, the degree of BALF "alveolitis" correlating with the severity of patient response.
European Respiratory Journal
Reynolds, S.P., Jones, K.P., Edwards, J.H. and Davies, B.H. (1993) 'Inhalation challenge in pigeon breeder's disease: BAL fluid changes after 6 hours', European Respiratory Journal, 6(4), pp.467-476.
This article was published in European Respiratory Journal in 1993, available at http://erj.ersjournals.com/content/6/4/467.short
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