Inhalation challenge in pigeon breeder's disease: BAL fluid changes after 6 hours
European Respiratory Society
MetadataDangos cofnod eitem llawn
The purpose of this study was to determine the cellular events occurring 6 h after bronchial inhalation challenge, in a group of pigeon breeders. Twelve subjects agreed to undergo challenge, either with nebulized pigeon serum (Ps) (n = 10), or with saline (n = 2). The development of characteristic symptoms was used to detect a positive response in combination with monitoring tests (white blood cell count (WBC), body temperature, and spirometry). An initial bronchoalveolar lavage (BAL) was performed before inhalation challenge, and a further BAL on the previously spared right middle lobe subsegment or lingula 6 h after challenge. Paired bronchoalveolar lavage fluid (BALF) samples were analysed for urea, albumin, total and differential WBC, interleukin-1 and interleukin-2. There was a significant increase in total cells, lymphocytes, T-lymphocytes, and neutrophils; numbers.ml-1 of BALF in responders. A monitoring score reflecting severity of patient response correlated with an increase in all cell types (p < 0.05). In conclusion, responders developed both a BALF lymphocytic and neutrophilic "alveolitis" following inhalation challenge, the degree of BALF "alveolitis" correlating with the severity of patient response.
European Respiratory Journal
Reynolds, S.P., Jones, K.P., Edwards, J.H. and Davies, B.H. (1993) 'Inhalation challenge in pigeon breeder's disease: BAL fluid changes after 6 hours', European Respiratory Journal, 6(4), pp.467-476.
This article was published in European Respiratory Journal in 1993, available at http://erj.ersjournals.com/content/6/4/467.short
- Un-themed 
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
Newly qualified practitioners’ perceptions of the definition and management of challenging behaviour on the paediatric caseload Jones, Cain Eleri (Cardiff Metropolitan University, 2016)Background: Due to the apparent comorbid relationship between speech language and communication difficulties (SLCD) and challenging behaviour (Kevan, 2003; Campbell 1995) speech and language therapists (SLTs) are very ...
Joyce, T.; Ditchfield, H.; Harris, Philip (Wiley, published on behalf of MENCAP and in association with IASSID, 2001-04-01)The implementation of community care in the UK has led to the requirement that services should be able to meet the needs of adults with intellectual disability (ID) and additional needs in terms of challenging behaviour. ...
An investigation into the challenges faced by festival organisers in the attempt to make festivals environmentally sustainable Wild, Victoria Louise (Cardiff Metropolitan University, 2010)The aim of the study was to highlight, explore and evaluate the key challenges that music festival organisers are facing whilst implementing environment protection schemes. This aim was achieved through conducting both ...