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dc.contributor.authorReynolds, S.P.
dc.contributor.authorJones, Ken
dc.contributor.authorEdwards, J.H.
dc.contributor.authorDavies, B.H.
dc.identifier.citationReynolds, S.P., Jones, K.P., Edwards, J.H. and Davies, B.H. (1993) 'Inhalation challenge in pigeon breeder's disease: BAL fluid changes after 6 hours', European Respiratory Journal, 6(4), pp.467-476.en_US
dc.descriptionThis article was published in European Respiratory Journal in 1993, available at
dc.description.abstractThe purpose of this study was to determine the cellular events occurring 6 h after bronchial inhalation challenge, in a group of pigeon breeders. Twelve subjects agreed to undergo challenge, either with nebulized pigeon serum (Ps) (n = 10), or with saline (n = 2). The development of characteristic symptoms was used to detect a positive response in combination with monitoring tests (white blood cell count (WBC), body temperature, and spirometry). An initial bronchoalveolar lavage (BAL) was performed before inhalation challenge, and a further BAL on the previously spared right middle lobe subsegment or lingula 6 h after challenge. Paired bronchoalveolar lavage fluid (BALF) samples were analysed for urea, albumin, total and differential WBC, interleukin-1 and interleukin-2. There was a significant increase in total cells, lymphocytes, T-lymphocytes, and neutrophils; of BALF in responders. A monitoring score reflecting severity of patient response correlated with an increase in all cell types (p < 0.05). In conclusion, responders developed both a BALF lymphocytic and neutrophilic "alveolitis" following inhalation challenge, the degree of BALF "alveolitis" correlating with the severity of patient response.en_US
dc.publisherEuropean Respiratory Societyen_US
dc.relation.ispartofseriesEuropean Respiratory Journal
dc.titleInhalation challenge in pigeon breeder's disease: BAL fluid changes after 6 hoursen_US

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