Rapid intravascular injection into limb skeletal muscle: a damage assessment study

Abstract

This study explored the use of gene therapy to accelerate the repair of muscle injury and investigated how rapid intra-arterial and intravenous injections influence limb muscle cell morphology and repair as well as inflammatory response. The rapid injection protocol led to the immediate development of interstitial oedema in the muscle but only low levels of myofiber damage were evident and this damage observed was transient in nature. This study demonstrates that these injection protocols may be effectively used to enhance rates of muscle repair and regeneration. Toumi collected the data and the histology and wrote / edited the manuscript.