Does the Her-2 status alter from the primary breast tumour to the lymph node metastasis?
Cardiff Metropolitan University
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Breast cancer affects approximately 45,000 women in the UK each year. Her-2/neu is found to be over-expressed in approximately 20 to 25% of breast cancer. Due to this treatments directed against to Her-2/neu have been developed such as Trastuzumab. Testing of the patients tumour for over-expression of Her-2/neu is performed on the primary tumour but testing of the lymph node metastasis could provide to be more beneficial to the patient. In the study 47 patients were tested, for the Her-2/neu status of the primary tumour and the axillary lymph node metastasis. Testing was performed by IHC using the 4B5 antibody (Ventana) and slides scored under current guidelines of 0, +1, +2 and +3. There were in total l5 changes from the primary tumour and the lymph node metastasis all ranging from either being down-graded or up-graded. Of the l5 changes, 7 changes resulted in being up-graded from their original Her-2/neu status. Statistical results showed that there was no significant changes in the Her-2/neu status from the primary tumour and the axillary lymph node.
MSc Biomedical Science
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