An investigation into the role of a raised %Hypo as a tool in detecting early anaemia
Cardiff Metropolitan University
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Iron deficiency is the most common cause of anaemia worldwide. The aim of this study was to investigate the significance of a raised %oHypo in determining iron deficiency anaemia in subjects with normal haemoglobin (Hb) and red cell indices (including reticulocyte parameters). Whilst Hb is the most commonly used haematological screening test an individual needs to loose a large proportion of their iron stores before this is reflected by a reduced Hb below the normal range. Serum ferritin is the current diagnostic test for anaemia however, it is a positive acute phase reactant and so is inaccurate in cases of inflammation as in Anaemia of Chronic Disease. %Hypo in conjunction with other parameters has been used in haemodialysis patients to assess iron availability. Sixty patients selected from outpatient clinics and GP surgeries were categorised based on their red cell indices into three groups 1. normal, 2. anaemic and 3. the test group: normal Hb, red cell indices and raised %Hypo. Soluble Transferrin Receptor (sTfR), Serum ferritin and C - reactive protein levels were used to ascertain whether there is any evidence of Iron Deficiency Anaemia or Anaemia of Chronic Disease. sTfR was used as the gold standard measurement of iron stores. Statistical analysis demonstrated that there were significant differences between the main indices (p=<0.05) between the three groups. However %Hypo was not significant (p=0.89) in determining anaemia in the test group when using sTfR as the gold standard. Conversely Reticulocyte haemoglobin content (CHr) was significant (p=0.011). From these results it is proposed that %Hypo is used as an initial screen and a subsequent reticulocyte count conducted to identify anaemia earlier than the current methods.
MSc Biomedical Science
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