A demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honey
Springer Berlin Heidelberg
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Pseudomonas and Burkholderia pose a significant health threat to people with chronic respiratory conditions; the resistance inherent in these bacteria indicates that new antimicrobial strategies are required. Susceptibility of 56 strains of P. aeruginosa and 55 strains of Burkholderia to manuka honey, tobramycin and colistin using microbroth dilution and E strip was determined. MICs of antibiotics with honey were determined to search for synergistic combinations against two representative strains of each genus. All strains exhibited susceptibility to honey ≤10 % (w/v); mean susceptibility of Burkholderia (4.6 % w/v) was lower than P. aeruginosa (7.3 % w/v). Synergistic or additive combinations were found with all four strains tested. Combinations of manuka honey with antibiotics can be used to lower the MIC need to successfully inhibit both P. aeruginosa and B. cepacia. The use of honey as a combination agent may be possible for the management of P. aeruginosa and B. cepacia.
Archives of Microbiology;
Jenkins, R., Wootton, M., Howe, R. and Cooper, R. (2015) 'A demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honey', Archives of Microbiology, 197 (4), pp. 597-601
Dynodwr Gwrthrych Digidol (DOI)http://dx.doi.org/10.1007/s00203-015-1091-6
This article was published in Archives of Microbiology on 14 February 2015 (online), available open access at: http://dx.doi.org/10.1007/s00203-015-1091-6
Funded by The Waterloo Foundation and The Sir Halley Stewart Trust
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Kronda, J.M.; Cooper, Rose; Maddocks, Sarah (Wiley, 2013)Aims: The aim of this study was to determine whether manuka honey affected siderophore production by three strains of Pseudomonas aeruginosa. Methods and results: The minimum inhibitory concentration (MIC) of manuka ...
Manuka honey treatment of biofilms of Pseudomonas aeruginosa results in the emergence of isolates with increased honey resistance Camplin, A. L.; Maddocks, Sarah (BioMed Central, 2014)Background Medical grade manuka honeys are well known to be efficacious against Pseudomonas aeruginosa being bactericidal and inhibiting the development of biofilms; moreover manuka honey effectively kills P. aeruginosa ...
John, David (University of Wales Institute Cardiff, 2012)Introduction The antibacterial effects and mode of action of medical honeys such as the increasingly well known manuka honey are currently under investigation. In order for these to be considered for use as a mainstream ...