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dc.contributor.authorJenkins, Rowena
dc.contributor.authorWootton, Mandy
dc.contributor.authorHowe, Robin
dc.contributor.authorCooper, Rose
dc.date.accessioned2016-02-19T17:16:47Z
dc.date.available2016-02-19T17:16:47Z
dc.date.issued2015
dc.identifier.citationJenkins, R., Wootton, M., Howe, R. and Cooper, R. (2015) 'A demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honey', Archives of Microbiology, 197 (4), pp. 597-601en_US
dc.identifier.issn0302-8933
dc.identifier.issn1432-072X (online)
dc.identifier.urihttp://hdl.handle.net/10369/7716
dc.descriptionThis article was published in Archives of Microbiology on 14 February 2015 (online), available open access at: http://dx.doi.org/10.1007/s00203-015-1091-6
dc.description.abstractPseudomonas and Burkholderia pose a significant health threat to people with chronic respiratory conditions; the resistance inherent in these bacteria indicates that new antimicrobial strategies are required. Susceptibility of 56 strains of P. aeruginosa and 55 strains of Burkholderia to manuka honey, tobramycin and colistin using microbroth dilution and E strip was determined. MICs of antibiotics with honey were determined to search for synergistic combinations against two representative strains of each genus. All strains exhibited susceptibility to honey ≤10 % (w/v); mean susceptibility of Burkholderia (4.6 % w/v) was lower than P. aeruginosa (7.3 % w/v). Synergistic or additive combinations were found with all four strains tested. Combinations of manuka honey with antibiotics can be used to lower the MIC need to successfully inhibit both P. aeruginosa and B. cepacia. The use of honey as a combination agent may be possible for the management of P. aeruginosa and B. cepacia.en_US
dc.description.sponsorshipFunded by The Waterloo Foundation and The Sir Halley Stewart Trust
dc.language.isoenen_US
dc.publisherSpringer Berlin Heidelbergen_US
dc.relation.ispartofseriesArchives of Microbiology;
dc.subjectcystic fibrosisen_US
dc.subjectpseudomonas aeruginosaen_US
dc.subjectburkholderia cepaciaen_US
dc.subjectmanuka honeyen_US
dc.subjectsynergyen_US
dc.titleA demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honeyen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00203-015-1091-6
dc.date.dateAccepted2015-02-06


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