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Increased monocyte actin polymerization in rat blood after intratracheal instillation of air pollution particles

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Author
Adams, Rachel
Al-Mosawi, Ameena
Bérubé, Kelly
Jones, Tim
Higgins, Timothy
Evans, Shelley-Ann
Date
2014
Type
Article
Publisher
IOS Press Content Library
ISSN
0006-355X
Metadata
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Abstract
BACKGROUND: Exposure to particulate air pollution is associated with an increased risk of cardiovascular disease. The mechanism by which exposure increases risk is poorly understood but could involve changes in the flow properties of blood. OBJECTIVE: The aim of this investigation was to assess the effect, in rats, of intratracheal instillation of particulate air pollution on leukocyte flow properties by measurement of polymorphonucleocyte (PMN) and monocyte actin polymerisation. METHODS: Rats were exposed to particulate air pollution by intratracheal instillation of PM10. Blood was collected from test and control animals at 3 days (n=10) and 6 weeks (n=10) after dust instillation. Partial differential leukocyte counts were performed. The intracellular F-actin content of blood PMNs and monocytes was determined by staining with FITC-phalloidin and flow cytometric determination of mean florescence intensity (MFI). RESULTS: There were no significant changes in PMN MFI (p=0.369, ANOVA) or cell counts (p=0.753, ANOVA). There was a significant increase in monocyte MFI (p=0.004, ANOVA) and a decrease in monocyte cell count (p=0.003, ANOVA) in instilled rats. CONCLUSIONS: Intratracheal instillation of air pollution particles resulted in an increase in blood monocyte actin polymerisation, which may cause trapping of monocytes. This could be a mechanism by which exposure to air pollution increases the risk of cardiovascular disease.
Journal/conference proceeding
Biorheology;
Citation
Adams, R.A., Al-Mosawi, A., Berube, K., Jones, T., Higgins, T. and Evans, S-A (2014) 'Increased monocyte actin polymerization in rat blood after intratracheal instillation of air pollution particles', Biorheology, 51, pp. 329-338
URI
http://hdl.handle.net/10369/7717
DOI
http://dx.doi.org/10.3233/BIR-14027
Description
This article was published in Biorheology in 2014. The final published version is freely available at: http://dx.doi.org/10.3233/BIR-14027.
Rights
Non-commercial use only
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  • Cardiovascular Health and Ageing [100]

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