A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism
Lawrence, Matthew J.
Pillai, Suresh G.
Davidson, Simon J.
D'Silva, Lindsay A.
Curtis, Daniel J.
Brown, Martin R.
Weisel, John W.
Williams, Phylip R.
Evans, Phillip A.
Wiley Online Library
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This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The ‘abnormal’ clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence
British Journal of Haematology;
Lawrence, M. J., Sabra, A., Mills, G., Pillai, S. G., Abdullah, W., Hawkins, K., Morris, R. H. K., Davidson, S. J., D'Silva, L. A., Curtis, D. J., Brown, M. R., Weisel, J. W., Williams, P. R. and Evans, P. A. (2015) 'A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism', British Journal of Haematology, 168 (4), pp. 571–575.
This article was published in British Journal of Haematology on 10th October 2014 (online), available at http://dx.doi.org/10.1111/bjh.13173
National Institute of Social Care and Health Research Engineering and Physical Sciences Research Council
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