Antibiotic resistance among clinical Ureaplasma isolates recovered from neonates in England and Wales between 2007 and 2013

View/ open
Author
Beeton, Michael L.
Chalker, Victoria J.
Jones, Lucy C.
Maxwell, Nicola C.
Spiller, O. Brad
Date
2015Type
Article
Publisher
American Society for Microbiology
ISSN
0066-4804
Metadata
Show full item recordAbstract
Ureaplasma spp. are associated with numerous clinical sequelae with treatment options being limited due to patient and pathogen factors. This report examines the prevalence and mechanisms of antibiotic resistance among clinical strains isolated from 95 neonates, 32 women attending a sexual health clinic, and 3 patients under investigation for immunological disorders, between 2007 and 2013 in England and Wales. MICs were determined by using broth microdilution assays, and a subset of isolates were compared using the broth microdilution method and the Mycoplasma IST2 assay. The underlying molecular mechanisms for resistance were determined for all resistant isolates. Three isolates carried the tet(M) tetracycline resistance gene (2.3%; confidence interval [CI], 0.49 to 6.86%); two isolates were ciprofloxacin resistant (1.5%; CI, 0.07 to 5.79%) but sensitive to levofloxacin and moxifloxacin, while no resistance was seen to any macrolides tested. The MIC values for chloramphenicol were universally low (2 μg/ml), while inherently high-level MIC values for gentamicin were seen (44 to 66 μg/ml). The Mycoplasma IST2 assay identified a number of false positives for ciprofloxacin resistance, as the method does not conform to international testing guidelines. While antibiotic resistance among Ureaplasma isolates remains low, continued surveillance is essential to monitor trends and threats from importation of resistant clones.
Journal/conference proceeding
Antimicrobial Agents and Chemotherapy
Citation
Beeton, M.L., Chalker, V.J., Jones, L.C., Maxwell, N.C. & Spiller, O.B. (2016) 'Antibiotic resistance among clinical Ureaplasma isolates recovered from neonates in England and Wales between 2007 and 2013', Antimicrobial Agents and Chemotherapy 60 (1), pp.52–56.
Description
This article was published in Antimicrobial Agents and Chemotherapy on 12th October 2015 (online), available at http://dx.doi.org/10.1128/AAC.00889-15.
Rights
Non-commercialCollections
Related items
Showing items related by title, author, subject and abstract.
-
THE ACUTE EFFECTS OF ASSISTED AND RESISTED PLYOMETRIC EXERCISES AS POTENTIATING EXERCISES FOR VERTICAL JUMP PERFORMANCE
Shield, Callum (Cardiff Metropolitan University, 2015)Aim: The aim of the present study was to investigate the acute effects of assisted and resisted plyometric exercises as potentiating exercises for vertical jump performance (VJP). Method: 11 male university level trained ... -
THE ACUTE EFFECTS OF ASSISTED AND RESISTED THE ACUTE EFFECTS OF ASSISTED AND RESISTED
Shields, Callum (Cardiff Metropolitan University, 2015)Aim: The aim of the present study was to investigate the acute effects of assisted and resisted plyometric exercises as potentiating exercises for vertical jump performance (VJP). Method: 11 male university level trained ... -
Heart rate and post exercise blood pressure responses to breathing methods during high intensity weight lifting
Mould, Luke (Cardiff Metropolitan University, 2016-04-06)Introduction: The Valsalva manoeuvre is defined at a prolonged expiration of breath against a closed glottis to the end of increasing intra-thoracic and intra-abdominal pressure. It is used during high intensity weight ...