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dc.contributor.authorZalli, Argita
dc.contributor.authorCarvalho, Livia A.
dc.contributor.authorLin, Jue
dc.contributor.authorHamer, Mark
dc.contributor.authorErusalimsky, Jorge
dc.contributor.authorBlackburn, Elizabeth H.
dc.contributor.authorSteptoe, Andrew
dc.date.accessioned2016-03-03T13:33:09Z
dc.date.available2016-03-03T13:33:09Z
dc.date.issued2014
dc.identifier.citationZalli, A., Carvalho, L.A., Lin, J., Hamer, M., Erusalimsky, J.D., Blackburn, E.H. and Steptoe, A. (2014) 'Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources', Proceedings of the National Academy of Sciences, 111 (12), pp.4519-4524.en_US
dc.identifier.otherESSN 1091-6490
dc.identifier.urihttp://hdl.handle.net/10369/7744
dc.descriptionThis article was published in Proceedings of the National Academy of Sciences on 10th March 2014 (online), available open access at http://dx.doi.org/10.1073/pnas.1322145111en_US
dc.description.abstractRecent work has linked psychological stress with premature cellular aging as indexed by reduced leukocyte telomere length. The combination of shorter telomeres with high telomerase activity (TA) may be indicative of active cell stress. We hypothesized that older individuals characterized by shorter telomeres with high TA in unstimulated leukocytes would show signs of high allostatic load and low levels of protective psychosocial resources. We studied 333 healthy men and women aged 54–76 y who underwent laboratory testing in which we measured cardiovascular, neuroendocrine, and inflammatory responses to standardized mental stress tasks. The tasks elicited prompt increases in blood pressure (BP), heart rate, cortisol, and mediators of inflammation and reductions in heart rate variability, returning toward baseline levels following stress. However, men having shorter telomeres with high TA showed blunted poststress recovery in systolic BP, heart rate variability, and monocyte chemoattractant protein-1, together with reduced responsivity in diastolic BP, heart rate, and cortisol, in comparison to men with longer telomeres or men with shorter telomeres and low TA. Shorter telomeres with high TA were also associated with reduced social support, lower optimism, higher hostility, and greater early life adversity. These effects were independent of age, socioeconomic status, and body mass index. We did not observe differences among older women. Our findings suggest that active cell stress is associated with impaired physiological stress responses and impoverished psychosocial resources, reflecting an integration of cellular, systemic, and psychological stress processes potentially relevant to health in older men.en_US
dc.language.isoenen_US
dc.publisherProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.relation.ispartofseriesProceedings of the National Academy of Sciences (PNAS)
dc.subjectcellular senescenceen_US
dc.subjectallostasisen_US
dc.subjectpsychological distressen_US
dc.titleShorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resourcesen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1073/pnas.1322145111
dc.date.dateAccepted2014-03-25


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