The antimicrobial and antibiofilm activities of copper(II) complexes
Beeton, Michael L.
Aldrich-Wright, Janice R.
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Biofilm-related bacterial infections pose a significant problem, as they are generally more tolerant to antibiotics and the immune system. Development of novel compounds with antibiofilm activity is therefore paramount. In this study we have analysed metal complexes of the general structure [M(IL)(AL)]2 + (where IL represents functionalised 1,10-phenanthrolines and AL represents 1S,2S- or 1R,2R-diaminocyclohexane) and [Cu(IL)3]2 +. Antimicrobial activity was tested on a number of bacterial strains, showing that copper(II) compounds were active against both Gram-positive and Gram-negative bacteria, albeit that activity was generally higher for the former. The antibiofilm activity was then determined against a clinical isolate of meticillin-resistant Staphylococcus aureus (MRSA). Strikingly, the copper complexes tested showed significant activity against biofilms, and were better in the removal of biofilms than vancomycin, an antibiotic that is currently used in the treatment of MRSA infections.
Journal of Inorganic Biochemistry
Beeton M. L., Aldrich-Wright. J. & Bolhuis A. (2014) 'The antimicrobial and antibiofilm activities of copper(II) complexes', Journal of Inorganic Biochemistry. 140, pp.167-172.
This article was published in Journal of Inorganic Biochemistry on 22nd July 2014 (online), available at http://dx.doi.org/10.1016/j.jinorgbio.2014.07.012 The author's post-print was made available in this repository from 22nd July 2016
RightsCreative Commons Attribution Non-Commercial No Derivatives License
Except where otherwise noted, this item's license is described as Creative Commons Attribution Non-Commercial No Derivatives License
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