Matrix Metalloproteinase-9 and Augmentation Index are reduced with an 8-week green-exercise walking programme
Thompson, Jane. E.S
MetadataDangos cofnod eitem llawn
Objectives: MMP-9 is involved in degrading the Extracellular Matrix (ECM); specifically elastin, which provides elasticity to the arterial wall. Elastin degradation and restructuring of the ECM results in increased vascular remodelling and arterial stiffness. Conversely, exercise improves age-related vascular stiffening. Therefore, this study aimed to investigate whether participation in a green-exercise programme affects vascular haemodynamics and mRNA expression of MMP-9. Methods: Thirty-six healthy, sedentary individuals (44 ± 2yrs; not taking any cardiovascular-acting medication) joining a moderate-intensity, aerobic green-exercise programme, were recruited. At baseline and 8-weeks into the programme, physical activity (measured in weekly MET-minutes [IPAQ]), supine Mean Arterial Blood Pressure (MAP), Augmentation Index (AIx) and aortic Pulse Wave Velocity (aPWV) data were collected and blood samples were obtained. Leukocytic MMP-9 mRNA expression (RT-PCR) and plasma protein levels (ELISA) were analysed; AIx and aPWV were measured via applanation tonometry (SphygmoCor, Atcor Medical, Australia). Results: The cohort was split into those who adhered (n=17) and did not adhere (n=19) to the programme. MMP-9 expression, MAP and AIx all decreased significantly in the exercise-adherent group (cf. the non-adherent group), while significant correlations were seen between: (i) ΔMMP-9 expression and ΔMET-minutes/wk; (ii) ΔMMP-9 expression and ΔAIx; (iii) ΔAIx and ΔMET-minutes/wk (P<0.05 in all cases). aPWV did not change significantly between the groups. Conclusions: These findings suggest that exercise-induced down-regulation of MMP-9 may contribute to reduced ECM degradation and therefore ameliorate vascular remodelling. Additional studies are needed to explore these findings further; however, these data may provide a biomolecular mechanism for aerobic exercises ability to delay age-related increases in arterial stiffening.
Journal of Hypertension;
Thompson JES, Webb R, Hewlett P, Llewellyn D, Mcdonnell BJ (2013) 'Matrix Metalloproteinase-9 and Augmentation Index are reduced with an 8-week green-exercise walking programme', Journal of Hypertension 2:127. doi: 10.4172/2167-1095.1000127
Dynodwr Gwrthrych Digidol (DOI)http://dx.doi.org/10.4172/2167-1095.1000127
This article was published in Journal of Hypertension on 3 October 2013 (online), available at http://dx.doi.org/10.4172/2167-1095.1000127
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Evaluation of cardiovascular risk-lowering health benefits accruing from laboratory-based, community-based and exercise-referral exercise programmes Webb, Richard; Thompson, J.E.S.; Ruffino, José; Davies, Nia; Watkeys, Laura; Hooper, S.; Jones, Paul M.; Walters, Gareth; Clayton, Debbie; Morris, Keith; Llewellyn, D.H.; Ward, M.; Wyatt-Williams, J.; McDonnell, Barry (British Medical Journal, 2016-03-01)Background To evaluate the ability of community-based exercise programmes to facilitate public participation in exercise and hence improved cardiovascular health, we assessed the respective impacts of: a continuously ...
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