Show simple item record

dc.contributor.authorMcDonnell, Barry
dc.contributor.authorThompson, Jane. E.S
dc.contributor.authorWebb, Richard
dc.contributor.authorHewlett, Paul
dc.contributor.authorLlewellyn, David
dc.date.accessioned2016-03-14T11:31:45Z
dc.date.available2016-03-14T11:31:45Z
dc.date.issued2013
dc.identifier.citationThompson JES, Webb R, Hewlett P, Llewellyn D, Mcdonnell BJ (2013) 'Matrix Metalloproteinase-9 and Augmentation Index are reduced with an 8-week green-exercise walking programme', Journal of Hypertension 2:127. doi: 10.4172/2167-1095.1000127en_US
dc.identifier.issn2167-1095
dc.identifier.urihttp://www.omicsgroup.org/journals/matrix-metalloproteinase-and-augmentation-index-are-reduced-with-an-week-greenexercise-walking-programm-2167-1095.1000127.php?aid=19345
dc.identifier.urihttp://hdl.handle.net/10369/7766
dc.descriptionThis article was published in Journal of Hypertension on 3 October 2013 (online), available at http://dx.doi.org/10.4172/2167-1095.1000127en_US
dc.description.abstractObjectives: MMP-9 is involved in degrading the Extracellular Matrix (ECM); specifically elastin, which provides elasticity to the arterial wall. Elastin degradation and restructuring of the ECM results in increased vascular remodelling and arterial stiffness. Conversely, exercise improves age-related vascular stiffening. Therefore, this study aimed to investigate whether participation in a green-exercise programme affects vascular haemodynamics and mRNA expression of MMP-9. Methods: Thirty-six healthy, sedentary individuals (44 ± 2yrs; not taking any cardiovascular-acting medication) joining a moderate-intensity, aerobic green-exercise programme, were recruited. At baseline and 8-weeks into the programme, physical activity (measured in weekly MET-minutes [IPAQ]), supine Mean Arterial Blood Pressure (MAP), Augmentation Index (AIx) and aortic Pulse Wave Velocity (aPWV) data were collected and blood samples were obtained. Leukocytic MMP-9 mRNA expression (RT-PCR) and plasma protein levels (ELISA) were analysed; AIx and aPWV were measured via applanation tonometry (SphygmoCor, Atcor Medical, Australia). Results: The cohort was split into those who adhered (n=17) and did not adhere (n=19) to the programme. MMP-9 expression, MAP and AIx all decreased significantly in the exercise-adherent group (cf. the non-adherent group), while significant correlations were seen between: (i) ΔMMP-9 expression and ΔMET-minutes/wk; (ii) ΔMMP-9 expression and ΔAIx; (iii) ΔAIx and ΔMET-minutes/wk (P<0.05 in all cases). aPWV did not change significantly between the groups. Conclusions: These findings suggest that exercise-induced down-regulation of MMP-9 may contribute to reduced ECM degradation and therefore ameliorate vascular remodelling. Additional studies are needed to explore these findings further; however, these data may provide a biomolecular mechanism for aerobic exercises ability to delay age-related increases in arterial stiffening.en_US
dc.language.isoenen_US
dc.publisherOMICS Internationalen_US
dc.relation.ispartofseriesJournal of Hypertension;
dc.rightsCreative Commons Attribution License
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subjectmatrix metalloproteinase-9en_US
dc.subjectvascular remodellingen_US
dc.subjectarterial stiffnessen_US
dc.subjectwave reflectionen_US
dc.subjectaerobic exerciseen_US
dc.subjectgreen-exerciseen_US
dc.titleMatrix Metalloproteinase-9 and Augmentation Index are reduced with an 8-week green-exercise walking programmeen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.4172/2167-1095.1000127
dc.date.dateAccepted2013-09-30


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

Creative Commons Attribution License
Except where otherwise noted, this item's license is described as Creative Commons Attribution License