Show simple item record

dc.contributor.authorCooper, Rose
dc.contributor.authorBjarnsholt, T.
dc.contributor.authorAlhede, M.
dc.date.accessioned2016-03-24T10:47:23Z
dc.date.available2016-03-24T10:47:23Z
dc.date.issued2014
dc.identifier.citationCooper, R.A., Bjarnsholt, T. and Alhede, M. (2014) 'Biofilms in wounds: a review of present knowledge', Journal of Wound Care, 23(11), pp. 570-582en_US
dc.identifier.issn0969-0700
dc.identifier.urihttp://hdl.handle.net/10369/7810
dc.descriptionThis article was published in Journal of Wound Care on 06 November 2014 (online), available at http://dx.doi.org/10.12968/jowc.2014.23.11.570en_US
dc.description.abstractFollowing confirmation of the presence of biofilms in chronic wounds, the term biofilm became a buzzword within the wound healing community. For more than a century pathogens have been successfully isolated and identified from wound specimens using techniques that were devised in the nineteenth century by Louis Pasteur and Robert Koch. Although this approach still provides valuable information with which to help diagnose acute infections and to select appropriate antibiotic therapies, it is evident that those organisms isolated from clinical specimens with the conditions normally used in diagnostic laboratories are mainly in a planktonic form that is unrepresentative of the way in which most microbial species exist naturally. Usually microbial species adhere to each other, as well as to living and non-living surfaces, where they form complex communities surrounded by collectively secreted extracellular polymeric substances (EPS). Cells within such aggregations (or biofilms) display varying physiological and metabolic properties that are distinct from those of planktonic cells, and which contribute to their persistence. There are many factors that influence healing in wounds and the discovery of biofilms in chronic wounds has provided new insight into the reasons why. Increased tolerance of biofilms to antimicrobial agents explains the limited efficacy of antimicrobial agents in chronic wounds and illustrates the need to develop new management strategies. This review aims to explain the nature of biofilms, with a view to explaining their impact on wounds.en_US
dc.language.isoenen_US
dc.publisherEurope PMC Plusen_US
dc.relation.ispartofseriesJournal of Wound care
dc.subjectEPSen_US
dc.subjectanti-biofilm strategiesen_US
dc.subjectbiofilm detectionen_US
dc.subjectextracellular polymeric substancesen_US
dc.subjectimmune evasionen_US
dc.subjectwound chronicityen_US
dc.titleBiofilms in wounds: a review of present knowledgeen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.12968/jowc.2014.23.11.570
dc.date.dateAccepted2014


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following collection(s)

Show simple item record