Exercise Induced Left Ventricular Remodeling Among Competitive Athletes: A Phasic Phenomenon
Weiner, Rory B.
DeLuca, James R.
Wasfy, Meagan M.
Stöhr, Eric J.
Lewis, Gregory D.
Hutter, Adolph M.
Picard, Michael H.
Baggish, Aaron L.
American Heart Association
MetadataShow full item record
Background: Contemporary understanding of exercise-induced cardiac remodeling (EICR) is based on cross-sectional data and relatively short duration longitudinal studies. Temporal progression of EICR remains incompletely understood. Methods and Results: A longitudinal repeated measures study design using 2-dimensional and speckle-tracking echocardiography was used to examine “acute augmentation” phase (AAP; 90 days) and more extended “chronic maintenance” phase (CMP; 39 months) left ventricular (LV) structural and functional adaptations to endurance exercise training among competitive male rowers (n=12, age 18.6±0.5 years). LV mass was within normal limits at baseline (93±9 g/m2), increased after AAP (1057 g/m2; p=0.001), and further increased after CMP (11310 g/m2, p<0.001 for comparison to post-AAP). AAP LV hypertrophy was driven by LV dilation (ΔLVEDV = 93 mL/m2, p=0.004) with stable LV wall thickness (Δwall thickness = 0.30.1 mm, p=0.63). In contrast, CMP LV hypertrophy was attributable to LV wall thickening (Δ wall thickness = 1.10.4 mm, p=0.004) with stable LV chamber volumes (ΔLVEDV = 11 mL/m2, p=0.48). Early diastolic peak tissue velocity increased during AAP (-11.7±1.9 vs. -13.6±1.3 cm/s, p<0.001) and remained similarly increased after CMP. Conclusions: In a small sample of competitive endurance athletes, EICR follows a phasic response with increases in LV chamber size, early diastolic function, and systolic twist in an acute augmentation phase of exercise training. This is followed by a chronic phase of adaptation characterized by increasing wall thickness and regression in LV twist. Training duration is a determinant of EICR and has implications for the assessment of myocardial structure and function in athletes.
Circulation: Cardiovascular Imaging
Weiner RB, DeLuca JR, Wang F, Lin J, Wasfy MM, Berkstresser B, Stöhr E, Shave R, Lewis GD, Hutter AM Jr, Picard MH, Baggish AL.(2015) 'Exercise-induced left ventricular remodeling among competitive athletes: a phasic phenomenon', Circulation: Cardiovascular Imaging, 8(12), p.e003651
This article was published in Circulation: Cardiovascular Imaging on 14 December 2015 (online), available at http://dx.doi.org/10.1161/CIRCIMAGING.115.003651
- Sport Research Groups 
Showing items related by title, author, subject and abstract.
Heart rate and post exercise blood pressure responses to breathing methods during high intensity weight lifting Mould, Luke (Cardiff Metropolitan University, 2016-04-06)Introduction: The Valsalva manoeuvre is defined at a prolonged expiration of breath against a closed glottis to the end of increasing intra-thoracic and intra-abdominal pressure. It is used during high intensity weight ...
Impaired myocardial function does not explain reduced left ventricular filling and stroke volume at rest or during exercise at high altitude Stembridge, Mike; Ainslie, Philip; Hughes, Michael G.; Stöhr, Eric J.; Cotter, James D.; Tymko, Michael M.; Day, Trevor A.; Bakker, Akke; Shave, Rob (American Physiological Society, 2015-11-15)Impaired myocardial systolic contraction and diastolic relaxation have been suggested as possible mechanisms contributing to the decreased stroke volume (SV) observed at high altitude (HA). To determine whether intrinsic ...
Exercise-associated generation of PPARγ ligands activates PPARγ signaling events and upregulates genes related to lipid metabolism Thomas, A. W.; Davies, N. A.; Moir, H.; Watkeys, L.; Ruffino, J. S.; Isa, S. A.; Butcher, L. R.; Hughes, M. G.; Morris, K.; Webb, Richard (American Physiological Society, 2012)The aim of the present study was to test the hypotheses that exercise is associated with generation of peroxisome proliferator-activated receptor-γ (PPARγ) ligands in the plasma and that this may activate PPARγ signaling ...