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dc.contributor.authorWeiner, Rory B.
dc.contributor.authorDeLuca, James R.
dc.contributor.authorWang, Francis
dc.contributor.authorLin, Jeffrey
dc.contributor.authorWasfy, Meagan M.
dc.contributor.authorBerkstresser, Brant
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorShave, Rob
dc.contributor.authorLewis, Gregory D.
dc.contributor.authorHutter, Adolph M.
dc.contributor.authorPicard, Michael H.
dc.contributor.authorBaggish, Aaron L.
dc.date.accessioned2016-03-29T09:01:52Z
dc.date.available2016-03-29T09:01:52Z
dc.date.issued2015
dc.identifier.citationWeiner RB, DeLuca JR, Wang F, Lin J, Wasfy MM, Berkstresser B, Stöhr E, Shave R, Lewis GD, Hutter AM Jr, Picard MH, Baggish AL.(2015) 'Exercise-induced left ventricular remodeling among competitive athletes: a phasic phenomenon', Circulation: Cardiovascular Imaging, 8(12), p.e003651en_US
dc.identifier.issn1942-0080
dc.identifier.urihttp://hdl.handle.net/10369/7813
dc.identifier.urihttp://dx.doi.org/10.1161/CIRCIMAGING.115.003651
dc.descriptionThis article was published in Circulation: Cardiovascular Imaging on 14 December 2015 (online), available at http://dx.doi.org/10.1161/CIRCIMAGING.115.003651en_US
dc.description.abstractBackground: Contemporary understanding of exercise-induced cardiac remodeling (EICR) is based on cross-sectional data and relatively short duration longitudinal studies. Temporal progression of EICR remains incompletely understood. Methods and Results: A longitudinal repeated measures study design using 2-dimensional and speckle-tracking echocardiography was used to examine “acute augmentation” phase (AAP; 90 days) and more extended “chronic maintenance” phase (CMP; 39 months) left ventricular (LV) structural and functional adaptations to endurance exercise training among competitive male rowers (n=12, age 18.6±0.5 years). LV mass was within normal limits at baseline (93±9 g/m2), increased after AAP (1057 g/m2; p=0.001), and further increased after CMP (11310 g/m2, p<0.001 for comparison to post-AAP). AAP LV hypertrophy was driven by LV dilation (ΔLVEDV = 93 mL/m2, p=0.004) with stable LV wall thickness (Δwall thickness = 0.30.1 mm, p=0.63). In contrast, CMP LV hypertrophy was attributable to LV wall thickening (Δ wall thickness = 1.10.4 mm, p=0.004) with stable LV chamber volumes (ΔLVEDV = 11 mL/m2, p=0.48). Early diastolic peak tissue velocity increased during AAP (-11.7±1.9 vs. -13.6±1.3 cm/s, p<0.001) and remained similarly increased after CMP. Conclusions: In a small sample of competitive endurance athletes, EICR follows a phasic response with increases in LV chamber size, early diastolic function, and systolic twist in an acute augmentation phase of exercise training. This is followed by a chronic phase of adaptation characterized by increasing wall thickness and regression in LV twist. Training duration is a determinant of EICR and has implications for the assessment of myocardial structure and function in athletes.en_US
dc.language.isoenen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.ispartofseriesCirculation: Cardiovascular Imaging
dc.subjectexerciseen_US
dc.subjectmyocardiumen_US
dc.subjectremodelingen_US
dc.subjectechocardiographyen_US
dc.titleExercise Induced Left Ventricular Remodeling Among Competitive Athletes: A Phasic Phenomenonen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1161/CIRCIMAGING.115.003651
dc.date.dateAccepted2015-11-05
dc.rights.embargodate2016-06-14
dc.rights.embargoreason6 month embargo requested by publisher


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