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dc.contributor.authorPugh, Christopher J. A.
dc.contributor.authorSprung, Victoria S.
dc.contributor.authorKemp, Graham J.
dc.contributor.authorRichardson, Paul
dc.contributor.authorShojaee-Moradie, Fariba
dc.contributor.authorUmpleby, A. Margot
dc.contributor.authorGreen, Daniel J.
dc.contributor.authorCable, N. Timothy
dc.contributor.authorJones, Helen
dc.contributor.authorCuthbertson, Daniel J.
dc.contributor.othercmet = Chris Pugh
dc.date.accessioned2016-04-07T12:04:28Z
dc.date.available2016-04-07T12:04:28Z
dc.date.issued2014-11-01
dc.identifier.citationPugh C.J., Sprung V.S., Kemp G.J., Richardson P., Shojaee-Moradie F., Umpleby A.M., Green D.J., Cable N.T., Jones H. and Cuthbertson D.J. (2014) 'Exercise training reverses endothelial dysfunction in nonalcoholic fatty liver disease', American Journal of Physiology; Heart & Circulatory Physiology, 307(9), H1298-1306en_US
dc.identifier.issn0363-6135
dc.identifier.urihttp://hdl.handle.net/10369/7845
dc.descriptionThis article was published in American Journal of Physiology; Heart and Circulatory Physiology on 01 November 2014, available at http://dx.doi.org/10.1152/ajpheart.00306.2014en_US
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular disease (CVD). Endothelial dysfunction is an early manifestation of atherosclerosis and an important prognostic marker for future cardiovascular events. The aim of this study was twofold: to examine 1) the association between liver fat, visceral adipose tissue (VAT), and endothelial dysfunction in obese NAFLD patients and 2) the impact of supervised exercise training on this vascular defect. Brachial artery endothelial function was assessed by flow-mediated dilatation (FMD) in 34 obese NAFLD patients and 20 obese controls of similar age and cardiorespiratory fitness [peak oxygen uptake (V˙ O2 peak)] (48 ! 2 vs. 47 ! 2 yr; 27 ! 1 vs. 26 ! 2 ml·kg"1·min"1"1). Magnetic resonance imaging and spectroscopy quantified abdominal and liver fat, respectively. Twenty-one NAFLD patients completed either 16 wk of supervised moderate-intensity exercise training (n # 13) or conventional care (n # 8). Differences between NAFLD and controls were compared using independent t-tests and effects of interventions by analysis of covariance. NAFLD patients had higher liver fat [11.6% (95% CI # 7.4, 18.1), P $ 0.0005] and VAT [1.6 liters (95% CI # 1.2, 2.0), P $ 0.0001] than controls and exhibited impaired FMD compared with controls ["3.6% (95% CI # "4.9, "2.2), P $ 0.0001]. FMD was inversely correlated with VAT (r # "0.54, P # 0.001) in NAFLD, although the impairment in FMD remained following covariate adjustment for VAT [3.1% (95% CI # 1.8, 4.5), P $ 0.001]. Exercise training, but not conventional care, significantly improved V˙ O2 peak [9.1 ml·kg"1·min"1 (95% CI # 4.1, 14.1); P #0.001] and FMD [3.6% (95% CI # 1.6, 5.7), P # 0.002]. Endothelial dysfunction in NAFLD cannot be fully explained by excess VAT but can be reversed with exercise training; this has potential implications for the primary prevention of CVD in NAFLD.en_US
dc.description.sponsorshipWe would like to thank the European Foundation for the Study of Diabetes for funding this study [09/H1008/1]en_US
dc.language.isoenen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.ispartofseriesAmerican Journal of Physiology; Heart and Circulatory Physiology
dc.subjectNon-alcoholic fatty liver disease (NAFLD)en_US
dc.subjectflow mediated dilation (FMD)en_US
dc.subjectcardiovascular risken_US
dc.subjectexercise trainingen_US
dc.titleExercise training reverses endothelial dysfunction in nonalcoholic fatty liver diseaseen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1152/ajpheart.00306.2014
dc.date.dateAccepted2014-09-01


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