Point-of-care cardiac troponin I in non-domestic species: a feasibility study

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Author
Feltrer, Yedra
Strike, Tai
Routh, Andrew
Gaze, David
Shave, Rob
Date
2016Acceptance date
2016-04-04
Type
Article
Publisher
European Association of Zoos and Aquaria
ISSN
2214-7594
Metadata
Show full item recordAbstract
One of the main challenges faced by veterinary surgeons in the field of zoo and wild animal medicine
is the lack of published reference data and validated tests for non-domestic species. In the field of
cardiology the diagnostic techniques used for domestic animals are also applied to exotic species.
However due to the wide range of species dealt with and their different sizes, few techniques have
been validated. Recent advances in human and domestic animal medicine have shown cardiac
troponin I (cTnI) to be the biomarker of choice for myocardial damage. The primary aim of this
feasibility study was to determine whether the i-STAT®1 hand-held analyser can be used to identify
elevations of serum and plasma cTnI in a variety of non-domestic species. The secondary aim was
to explore whether elevations in cTnI were related to underlying cardiac pathology. During routine
health checks at the Zoological Society of London, 171 blood samples were collected from 36 different
species (27 mammal, seven bird and two reptile) and were analysed for cTnI using the i-STAT®1 handheld
analyser. Concentrations of cTnI below, equal to and well above a suggested cut-off of 0.08 μg/L
were observed in mammalian species. The majority of animals with concentrations of cTnI above 0.08
μg/L were subsequently shown to have pathology with potential cardiac involvement. All avian and
reptilian samples were below 0.00 μg/L even though overt cardiac pathology was noted in some of
these animals. In conclusion, the assessment of cTnI using the i-STAT®1 hand-held analyser shows
promise as a humoral marker of cardiac pathology in mammalian species but not for avian and reptilian
species. Further work is required to define species-specific reference intervals for cTnI.
Journal/conference proceeding
Journal of Zoo and Aquarium Research
Citation
Feltrer, Y., Strike, T., Routh, A., Gaze, D., & Shave, R. (2016) 'Point-of-care cardiac troponin I in non-domestic species: a feasibility study', Journal of Zoo and Aquarium Research, 4 (2), pp. 99-103.
Description
This article was published in Journal of Zoo and Aquarium Research on 30 April 2016 (online), available at http://www.jzar.org/jzar/article/view/172
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