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dc.contributor.authorFeltrer, Yedra
dc.contributor.authorStrike, Tai
dc.contributor.authorRouth, Andrew
dc.contributor.authorGaze, David
dc.contributor.authorShave, Rob
dc.date.accessioned2016-05-03T15:30:40Z
dc.date.available2016-05-03T15:30:40Z
dc.date.issued2016
dc.identifier.citationFeltrer, Y., Strike, T., Routh, A., Gaze, D., & Shave, R. (2016) 'Point-of-care cardiac troponin I in non-domestic species: a feasibility study', Journal of Zoo and Aquarium Research, 4 (2), pp. 99-103.en_US
dc.identifier.issn2214-7594
dc.identifier.urihttp://www.jzar.org/jzar/article/view/172
dc.identifier.urihttp://hdl.handle.net/10369/7875
dc.descriptionThis article was published in Journal of Zoo and Aquarium Research on 30 April 2016 (online), available at http://www.jzar.org/jzar/article/view/172en_US
dc.description.abstractOne of the main challenges faced by veterinary surgeons in the field of zoo and wild animal medicine is the lack of published reference data and validated tests for non-domestic species. In the field of cardiology the diagnostic techniques used for domestic animals are also applied to exotic species. However due to the wide range of species dealt with and their different sizes, few techniques have been validated. Recent advances in human and domestic animal medicine have shown cardiac troponin I (cTnI) to be the biomarker of choice for myocardial damage. The primary aim of this feasibility study was to determine whether the i-STAT®1 hand-held analyser can be used to identify elevations of serum and plasma cTnI in a variety of non-domestic species. The secondary aim was to explore whether elevations in cTnI were related to underlying cardiac pathology. During routine health checks at the Zoological Society of London, 171 blood samples were collected from 36 different species (27 mammal, seven bird and two reptile) and were analysed for cTnI using the i-STAT®1 handheld analyser. Concentrations of cTnI below, equal to and well above a suggested cut-off of 0.08 μg/L were observed in mammalian species. The majority of animals with concentrations of cTnI above 0.08 μg/L were subsequently shown to have pathology with potential cardiac involvement. All avian and reptilian samples were below 0.00 μg/L even though overt cardiac pathology was noted in some of these animals. In conclusion, the assessment of cTnI using the i-STAT®1 hand-held analyser shows promise as a humoral marker of cardiac pathology in mammalian species but not for avian and reptilian species. Further work is required to define species-specific reference intervals for cTnI.en_US
dc.language.isoenen_US
dc.publisherEuropean Association of Zoos and Aquariaen_US
dc.relation.ispartofseriesJournal of Zoo and Aquarium Research
dc.subjectbiomarkeren_US
dc.subjectcardiac pathologyen_US
dc.subjectcTnIen_US
dc.subjecthandheld analyseren_US
dc.titlePoint-of-care cardiac troponin I in non-domestic species: a feasibility studyen_US
dc.typeArticleen_US
dcterms.dateAccepted2016-04-04


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