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dc.contributor.authorWilliams, Alexandra
dc.contributor.authorShave, Rob
dc.contributor.authorStembridge, Mike
dc.contributor.authorEves, Neil
dc.date.accessioned2016-06-08T11:14:34Z
dc.date.available2016-06-08T11:14:34Z
dc.date.issued2016-07-01
dc.identifierhttps://repository.cardiffmet.ac.uk/bitstream/id/22053/Females%20have%20greater%20left%20ventricular%20twist%20mechanics%20than%20males-%20Shave%20R.pdf
dc.identifier.citationWilliams, A. M., Shave, R., Stembridge, M. & Eves, N. (2016) 'Females have greater left ventricular twist mechanics than males during acute reductions to preload', American Journal of Physiology - Heart and Circulatory Physiology, 311 (1), pp. 76-84en_US
dc.identifier.issn0363-6135
dc.identifier.issn1522-1539 (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/7914
dc.descriptionThis article was published in American Journal of Physiology - Heart and Circulatory Physiology on 13 May 2016 (online), available at http://dx.doi.org/10.1152/ajpheart.00057.2016en_US
dc.description.abstractBackground—Compared to males, females have smaller left ventricular (LV) dimensions and volumes, higher ejection fractions (EF), and higher LV longitudinal and circumferential strain. LV twist mechanics determine ventricular function, and are preload-dependent. Therefore, the sex differences in LV structure and myocardial function may result in different mechanics when preload is altered. This study investigated sex differences in LV mechanics during acute challenges to preload. Methods and Results—Using conventional and speckle-tracking echocardiography, LV structure and function were assessed in 20 males (24 ± 6.2 yr) and 20 females (23 ± 3.1 yr) at baseline and during progressive levels of lower body negative pressure (LBNP). Fourteen participants (8 males, 6 females) were also assessed following a rapid infusion of saline. LV end-diastolic volume, end-systolic volume, stroke volume (SV) and EF were reduced in both groups during LBNP (p<0.001). While males had greater absolute volumes (p<0.001) there were no sex differences in allometrically scaled volumes at any stage. Sex differences were not detected at baseline in basal rotation, apical rotation, or twist. Apical rotation and twist increased in both groups (p<0.001) with LBNP. At -60 mmHg, females had greater apical rotation (p=0.009), twist (p=0.008) and torsion (p=0.002), and faster untwisting velocity (p=0.02) than males. There were no differences in mechanics following saline infusion. Conclusions— Females have larger LV twist and a faster untwisting velocity than males during large reductions to preload, supporting that females have a greater reliance on LV twist mechanics to maintain SV during severe reductions to preload.en_US
dc.description.sponsorshipThis study was funded by the Natural Sciences and Engineering Research Council of Canada. A.M.W. is supported by the Natural Sciences and Engineering Research Council of Canada. N.D.E. is supported by the Michael Smith Foundation for Health Research
dc.language.isoenen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.ispartofseriesAmerican Journal of Physiology - Heart and Circulatory Physiology
dc.subjectsexen_US
dc.subjectmechanicsen_US
dc.subjectechocardiographyen_US
dc.titleFemales have greater left ventricular twist mechanics than males during acute reductions to preloaden_US
dc.typeArticleen_US
dc.typeacceptedVersion
dc.date.dateAccepted2016-05-09
dc.rights.embargodate2017-05-13
dc.rights.embargoreason12 month embargo requested by publisher
dcterms.dateAccepted2016-05-09
rioxxterms.versionAM
rioxxterms.versionofrecordhttp://dx.doi.org/10.1152/ajpheart.00057.2016
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.publicationdate2016-07-01
dc.date.refFCD2016-06-08
rioxxterms.freetoread.startdate2017-05-13


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