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dc.contributor.authorJohns, Benjamin
dc.contributor.authorPurdy, Kevin J.
dc.contributor.authorTucker, Nicholas P.
dc.contributor.authorMaddocks, Sarah
dc.identifier.citationJohns, B.E., Purdy, K.J., Tucker, N.P. and Maddocks, S.E. (2015) 'Phenotypic and genotypic characteristics of small colony variants and their role in chronic infection', Microbiology Insights, 8, p.15.en_US
dc.descriptionThis article was published in Microbiology Insights on 22 December 2015 (online), available open access at
dc.description.abstractSmall colony variant (SCV) bacteria arise spontaneously within apparently homogeneous microbial populations, largely in response to environmental stresses, such as antimicrobial treatment. They display unique phenotypic characteristics conferred in part by heritable genetic changes. Characteristically slow growing, SCVs comprise a minor proportion of the population from which they arise but persist by virtue of their inherent resilience and host adaptability. Consequently, SCVs are problematic in chronic infection, where antimicrobial treatment is administered during the acute phase of infection but fails to eradicate SCVs, which remain within the host causing recurrent or chronic infection. This review discusses some of the phenotypic and genotypic changes that enable SCVs to successfully proliferate within the host environment as potential pathogens and strategies that could ameliorate the resolution of infection where SCVs are present.en_US
dc.publisherLibertas Academica Pressen_US
dc.relation.ispartofseriesMicrobiology Insights
dc.rightsCreative Commons Attribution Non-Commercial License 3.0
dc.rightsCreative Commons Attribution License 3.0 only upon request
dc.titlePhenotypic and genotypic characteristics of small colony variants and their role in chronic infectionen_US

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