Nanoparticle technology to deliver effective antimicrobials
MetadataShow full item record
Bacterial resistance to antimicrobials emerged only a few years after the commercial availability of antibiotics. Nanotechnology offers a means by which new antimicrobials can be developed, or the lifespan of current antimicrobials can be extended. Nanoparticles are loosely defined as particles with at least one dimension smaller than 100 nm; their specific surface area, chemical and biological activity can be tuned for a desired application. As such they have become attractive within a variety of fields including medicine and, in particular, antimicrobial therapy. Nanoparticles with specific surface chemistry and size can intimately interact with the microbial surface mediating an antimicrobial effect that does not necessarily rely on the release of chemically active components. Moreover, nanoparticles can be incorporated into polymers or applied as coatings on surfaces, such as indwelling medical devices, making them extremely versatile; combined with a slow rate of release this means that they offer sustained antimicrobial activity.
American Journal of Microbiology
Maddocks,S. E., Barbour, M. E. and Collins, A. M. (2014) 'Nanoparticle technology to deliver effective antimicrobials', American Journal of Microbiology, 5 (2), pp. 35-36.
This article was published in American Journal of Microbiology in 2014, available open access at http://dx.doi.org/10.3844/ajmsp.2014.35.36
RightsCreative Commons Attribution License
Except where otherwise noted, this item's license is described as Creative Commons Attribution License
Showing items related by title, author, subject and abstract.
Roberts, Aled Edward Lloyd; Brown, Helen Louise; Jenkins, Rowena (Dove press, 2015-10-29)Antimicrobial resistance (AMR) is an increasing clinical problem precipitated by the inappropriate use of antibiotics in the later parts of the 20th Century. This problem, coupled with the lack of novel therapeutics in ...
The antimicrobial activity of Sudanese honeys alone and in combination with plant extracts and ethylenediamineteraacetic acid (edta) Hashim, Ahmed I. (Cardiff Metropolitan University, 2015)Honey and plant extracts have a long hitory of medicinal use in Sudan that continues to the present day. The antimicrobial properties of Manuka honey and its use as a topical wound treatment is now widely recognised but ...
Dual stimulation with bacterial and viral components increases the expression of hepcidin in human monocytes Ripley, D.A.; Morris, Keith; Maddocks, Sarah (Wiley Online Library, 2014)Hepcidin belongs to the antimicrobial peptide (AMP) family and is the key regulator of iron metabolism. It modulates iron homeostasis by binding to, and degrading the iron exporter molecule, ferroportin, thus inhibiting ...