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dc.contributor.authorTaleb, Hajer
dc.contributor.authorMorris, Keith
dc.contributor.authorWithycombe, Cathryn
dc.contributor.authorMaddocks, Sarah
dc.contributor.authorKanekanian, Ara
dc.date.accessioned2016-07-13T13:14:35Z
dc.date.available2016-07-13T13:14:35Z
dc.date.issued2016-02-22
dc.identifier.citationTaleb, H., Morris, R.K., Withycombe, C.E., Maddocks, S.E. and Kanekanian, A.D. (2016) 'Date syrup–derived polyphenols attenuate angiogenic responses and exhibits anti-inflammatory activity mediated by vascular endothelial growth factor and cyclooxygenase-2 expression in endothelial cells', Nutrition Research, 36(7), pp.636-647.en_US
dc.identifier.issn0271-5317
dc.identifier.issn1879-0739 (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/7971
dc.descriptionThis article was published in Nutrition Research on 22 February 2016 (online), available at http://dx.doi.org/10.1016/j.nutres.2016.02.010en_US
dc.description.abstractBioactive components such as polyphenols, present in many plants, are purported to have anti-inflammatory and antiangiogenic properties. Date syrup, produced from date fruit of the date palm tree, has traditionally been used to treat a wide range of diseases with etiologies involving angiogenesis and inflammation. It was hypothesized that polyphenols in date syrup reduce angiogenic responses such as cell migration, tube formation, and matrix metalloproteinase activity in an inflammatory model by exhibiting anti-inflammatory activity mediated by vascular endothelial growth factor (VEGF) and the prostaglandin enzyme cyclooxygenase-2 (COX-2) in endothelial cells. Date syrup polyphenols at 60 and 600μg/mL reduced inflammation and suppressed several stages of angiogenesis, including endothelial cell migration, invasion, matrix metalloproteinase activity, and tube formation, without evidence of cytotoxicity. VEGF and COX-2 expression induced by tumor necrosis factor–alpha at both gene expression and protein level was significantly reduced by date syrup polyphenols in comparison to untreated cells. In conclusion, polyphenols in date syrup attenuated angiogenic responses and exhibited anti-inflammatory activity mediated by VEGF and COX-2 expression in endothelial cells.en_US
dc.language.isoenen_US
dc.publisherScience Directen_US
dc.relation.ispartofseriesNutrition Research
dc.subjectangiogenesisen_US
dc.subjectpolyphenolsen_US
dc.subjectCyclooxygenase-2en_US
dc.subjectvascular endothelial growth factoren_US
dc.subjectinflammationen_US
dc.titleDate syrup derived polyphenols attenuate angiogenic responses and exhibits anti-inflammatory activity mediated by VEGF and COX-2 expression in endothelial cellsen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.nutres.2016.02.010
dc.date.dateAccepted2016-02-19
dc.rights.embargodate2017-02-22
dc.rights.embargoreason12 month embargo requested by publisher
rioxxterms.freetoread.startdate2017-02-22


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