A Photorhabdus natural product inhibits insect juvenile hormone Epoxide Hydrolase
Date
2015-03-16Type
Article
Publisher
Wiley Online Library
ISSN
1439-4227
1439-7633 (ESSN)
Metadata
Show full item recordAbstract
Simple urea compounds (“phurealipids”) have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.
Journal/conference proceeding
ChemBioChem;
Citation
Nollmann, F. I., Heinrich, A. K., Brachmann, A. O., Morisseau, C., Mukherjee, K., Casanova-Torres, Á. M., Strobl, F., Kleinhans, D., Kinski, S., Schultz, K., Beeton, M. L., Kaiser, M., Chu, Y.-Y., Phan Ke, L., Thanwisai, A., Bozhüyük, K. A. J., Chantratita, N., Götz, F., Waterfield, N. R., Vilcinskas, A., Stelzer, E. H. K., Goodrich-Blair, H., Hammock, B. D. and Bode, H. B. (2015), 'A Photorhabdus natural product inhibits insect juvenile hormone Epoxide Hydrolase', ChemBioChem, 16 (5), pp.766–771.
Description
This article was published in ChemBioChem on 25 February 2015 (online), available open access at http://dx.doi.org/10.1002/cbic.201402650
Rights
Creative Commons Attribution LicenseCollections
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