A Photorhabdus natural product inhibits insect juvenile hormone Epoxide Hydrolase

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Author
Nollmann, Friederike I.
Heinrich, Antje K.
Brachmann, Alexander L.
Morisseau, Christophe
Mukherjee, Krishnendu
Casanova-Torres, Angel M.
Strobl, Frederic
Kleinhans, David
Kinksi, Sebastian
Schultz, Katharina
Beeton, Michael L.
Kaiser, Marcel
Chu, Ya-Yun
Phan Ke, L.
Thanwisai, Aunchalee
Bozhüyük, Kenan A.J.
Chantratita, Narisara
Götz, Fredrich
Waterfield, Nick R.
Vilcinskas, Andreas
Stelzer, Ernst H.K.
Goodrich-Blair, Heidi
Hammock, Bruce D.
Bode, Helge B.
Date
2015-03-16
Type
Article
Publisher
Wiley Online Library
ISSN
1439-4227
1439-7633 (ESSN)
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Abstract
Simple urea compounds (“phurealipids”) have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.
Journal/conference proceeding
ChemBioChem;
Citation
Nollmann, F. I., Heinrich, A. K., Brachmann, A. O., Morisseau, C., Mukherjee, K., Casanova-Torres, Á. M., Strobl, F., Kleinhans, D., Kinski, S., Schultz, K., Beeton, M. L., Kaiser, M., Chu, Y.-Y., Phan Ke, L., Thanwisai, A., Bozhüyük, K. A. J., Chantratita, N., Götz, F., Waterfield, N. R., Vilcinskas, A., Stelzer, E. H. K., Goodrich-Blair, H., Hammock, B. D. and Bode, H. B. (2015), 'A Photorhabdus natural product inhibits insect juvenile hormone Epoxide Hydrolase', ChemBioChem, 16 (5), pp.766–771.
URI
http://dx.doi.org/10.1002/cbic.201402650
http://hdl.handle.net/10369/7972
Description
This article was published in ChemBioChem on 25 February 2015 (online), available open access at http://dx.doi.org/10.1002/cbic.201402650
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Except where otherwise noted, this item's license is described as Creative Commons Attribution License