Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing
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Aims: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials and methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis. Conclusions: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure.
Barbour, M.E., Maddocks, S.E., Grady, H.J., Roper, J.A., Bass, M.D., Collins, A.M., Dommett, R.M. and Saunders, M. (2016) 'Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing', Nanomedicine, 11(16), pp.2049-2057.
This article was published in Nanomedicine on 28 July 2016 (online), available open access at http://dx.doi.org/10.2217/nnm-2016-0084 The author's post-print is made available in this repository
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