Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing
Author
Barbour, Michele
Maddocks, Sarah
Grady, Helena
Roper, J.
Bass, Mark
Collins, Andrew
Dommett, Rachel
Saunders, Margaret
Date
2016Type
Article
Publisher
Future Medicine
ISSN
1743-5889
1748-6963 (ESSN)
Metadata
Show full item recordAbstract
Aims: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials.
Materials and methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure.
Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis.
Conclusions: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure.
Journal/conference proceeding
Nanomedicine
Citation
Barbour, M.E., Maddocks, S.E., Grady, H.J., Roper, J.A., Bass, M.D., Collins, A.M., Dommett, R.M. and Saunders, M. (2016) 'Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing', Nanomedicine, 11(16), pp.2049-2057.
Description
This article was published in Nanomedicine on 28 July 2016 (online), available open access at http://dx.doi.org/10.2217/nnm-2016-0084
The author's post-print is made available in this repository
Rights
Creative Commons Attribution 4.0 LicenceCollections
Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 Licence
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