Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ
MetadataDangos cofnod eitem llawn
Monocytes may be primed towards differentiation into classically activated M1 macrophages or alternatively activated M2 macrophages. M1 macrophages greatly contribute to the inflammation which promotes insulin resistance, whereas M2 macrophages resolve inflammation. We have previously shown that exercise increases M2 marker expression in mixed mononuclear cells, possibly via activation of the nuclear transcription factor PPARγ. However, these effects have not been demonstrated specifically within monocytes. Thus, we aimed to investigate whether moderate-intensity exercise elicited similar effects on monocytic M1/M2 marker expression and PPARγ activity to those reported previously in mononuclear cells, so as to further elucidate the mechanisms by which exercise may alter inflammatory status and, accordingly, prevent insulin resistance.
European Journal of Applied Physiology
Ruffino, J.S., Davies, N.A., Morris, K., Ludgate, M., Zhang, L., Webb, R. and Thomas, A.W. (2016) 'Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ', European Journal of Applied Physiology, pp.1-12.
Dynodwr Gwrthrych Digidol (DOI)http://dx.doi.org/10.1007/s00421-016-3414-y
This article was published in European Journal of Applied Physiology on 23 June 2016, available paid open access at http://dx.doi.org/10.1007/s00421-016-3414-y
HawliauCreative Commons Attribution 4.0 International
Funded by National Institute for Social Care and Health Research (Grant Number = HS/09/022). Jose Ruffino and Nia Davies were also recipients of the Welsh Government through Health and Care Research Wales studentships.
Oni nodir yn wahanol, disgrifir trwydded yr eitem hon fel a ganlyn Creative Commons Attribution 4.0 International
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
An investigation into the role of PPARγ and IL-6 in exercise-induced alterations in monocyte gene expression Ruffino, José (Cardiff Metropolitan University, 2015)The pro-inflammatory M1 macrophage phenotype is linked to insulin resistance, T2D and associated cardiovascular co-morbidities, whereas M2 macrophages regulate the M1 inflammatory response and are, thus, believed to be ...
Exercise-associated generation of PPARγ ligands activates PPARγ signaling events and upregulates genes related to lipid metabolism Thomas, A. W.; Davies, N. A.; Moir, H.; Watkeys, L.; Ruffino, J. S.; Isa, S. A.; Butcher, L. R.; Hughes, M. G.; Morris, K.; Webb, Richard (American Physiological Society, 2012)The aim of the present study was to test the hypotheses that exercise is associated with generation of peroxisome proliferator-activated receptor-γ (PPARγ) ligands in the plasma and that this may activate PPARγ signaling ...
Exercise-associated generation of PPARγ ligands activates PPARγ signalling events and upregulates genes related to lipid metabolism Thomas, Andrew; Davies, Nia; Moir, Hannah; Watkeys, Laura; Ruffino, José; Isa, S.A.; Butcher, Lee; Hughes, Michael G.; Morris, Keith; Webb, Richard (American Physiological Society, 2012)The aim of the present study was to test the hypotheses that exercise is associated with generation of peroxisome proliferator-activated receptor-γ (PPARγ) ligands in the plasma and that this may activate PPARγ signaling ...