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dc.contributor.authorRuffino, Jose
dc.contributor.authorDavies, Nia
dc.contributor.authorMorris, Keith
dc.contributor.authorLudgate, Marian
dc.contributor.authorZhang, L.
dc.contributor.authorWebb, Richard
dc.contributor.authorThomas, Andrew
dc.date.accessioned2016-07-21T13:30:33Z
dc.date.available2016-07-21T13:30:33Z
dc.date.issued2016-06-23
dc.identifier.citationRuffino, J.S., Davies, N.A., Morris, K., Ludgate, M., Zhang, L., Webb, R. and Thomas, A.W. (2016) 'Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ', European Journal of Applied Physiology, pp.1-12.en_US
dc.identifier.issn1439-6319
dc.identifier.issn1439-6327 (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/7981
dc.descriptionThis article was published in European Journal of Applied Physiology on 23 June 2016, available paid open access at http://dx.doi.org/10.1007/s00421-016-3414-yen_US
dc.description.abstractMonocytes may be primed towards differentiation into classically activated M1 macrophages or alternatively activated M2 macrophages. M1 macrophages greatly contribute to the inflammation which promotes insulin resistance, whereas M2 macrophages resolve inflammation. We have previously shown that exercise increases M2 marker expression in mixed mononuclear cells, possibly via activation of the nuclear transcription factor PPARγ. However, these effects have not been demonstrated specifically within monocytes. Thus, we aimed to investigate whether moderate-intensity exercise elicited similar effects on monocytic M1/M2 marker expression and PPARγ activity to those reported previously in mononuclear cells, so as to further elucidate the mechanisms by which exercise may alter inflammatory status and, accordingly, prevent insulin resistance.en_US
dc.description.sponsorshipFunded by National Institute for Social Care and Health Research (Grant Number = HS/09/022). Jose Ruffino and Nia Davies were also recipients of the Welsh Government through Health and Care Research Wales studentships.en_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofseriesEuropean Journal of Applied Physiology
dc.rightsCreative Commons Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectmonocyteen_US
dc.subjectpolarisationen_US
dc.subjectexerciseen_US
dc.subjectPPARγen_US
dc.subjectinsulin resistanceen_US
dc.titleModerate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s00421-016-3414-y
dc.date.dateAccepted2016-06-06
rioxxterms.funderNational Institute for Social Care and Health Research


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