Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in non-alcoholic fatty liver disease (NAFLD)
Pugh, Christopher J. A.
Umpleby, A. Margot
Green, Daniel J.
Cable, N. Timothy
Trennel, Michael I.
Kemp, Graham J.
Cuthbertson, Daniel J.
Nature Publishing Group
MetadataShow full item record
AIMS: Supervised exercise reduces liver fat and improves endothelial function, a surrogate of cardiovascular disease risk, in non-alcoholic fatty liver disease (NAFLD). We hypothesised that after a 16-week supervised exercise program, patients would maintain longer-term improvements in cardiorespiratory fitness, liver fat and endothelial function. MATHERIALS AND METHODS: Ten NAFLD patients [5/5 males/females, age 51±13years, BMI 31±3 kg.m2 (mean±s.d.)] underwent a 16-week supervised moderate-intensity exercise intervention. Biochemical markers, cardiorespiratory fitness (VO2peak), subcutaneous, visceral and liver fat (measured by magnetic resonance imaging and spectroscopy respectively) and brachial artery flow-mediated dilation (FMD) were assessed at baseline, after 16 weeks supervised training and 12-months after ending supervision. RESULTS: Despite no significant change in body weight, there were significant improvements in VO2peak [6.5 ml.kg−1.min−1 (95% CI 2.8, 10.1); P=0.003], FMD [2.9% (1.5, 4.2); P=0.001], liver transaminases (P<0.05) and liver fat [−10.1% (−20.6, 0.5); P=0.048] immediately after the 16-weeks supervised training. Nevertheless, 12-months after ending supervision, VO2peak [0.9 ml.kg−1.min−1 (−3.3 5.1); P=0.65], FMD [−0.07% (−2.3, 2.2); P=0.95], liver transaminases (P>0.05) and liver fat [1.4% (−13.0, 15.9); P=0.83] were not significantly different from baseline. CONCLUSIONS: Twelve months following cessation of supervision, exercise-mediated improvements in liver fat and other cardiometabolic variables had reversed with cardiorespiratory fitness at baseline levels. Maintenance of high cardiorespiratory fitness and stability of body weight are critical public health considerations for the treatment of NAFLD.
International Journal of Obesity
Pugh, C.J.A., Sprung, V.S., Jones, H., Richardson, P., Shojaee-Moradie, F., Umpleby, A.M., Green, D.J., Cable, N.T., Trenell, M.I., Kemp, G.J. and Cuthbertson, D.J. (2016) 'Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in non-alcoholic fatty liver disease (NAFLD)', International Journal of Obesity, 40(12), pp.1927-1930
This article was published in International Journal of Obesity on 21 July 2016 (online ahead of print), available at http://dx.doi.org/10.1038/ijo.2016.123
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
- Import 
Showing items related by title, author, subject and abstract.
Dissociation between exercise-induced reduction in liver fat and changes in hepatic and peripheral glucose homoeostasis in obese patients with non-alcoholic fatty liver disease Cuthbertson, Daniel; Shojaee-Moradie, Fariba; Sprung, Victoria; Jones, Helen; Pugh, Christopher J. A.; Richardson, Paul; Kemp, Graham; Barrett, Mark; Jackson, Nicola; Thomas, Louise; Bell, Jimmy; Umpleby, Margot (Portland Press, 2015-12-09)Non-alcoholic fatty liver disease (NAFLD) is associated with multi-organ (hepatic, skeletal muscle, adipose tissue) insulin resistance (IR). Exercise is an effective treatment for lowering liver fat but its effect on IR ...
Pugh, Christopher J. A.; Sprung, Victoria S.; Kemp, Graham J.; Richardson, Paul; Shojaee-Moradie, Fariba; Umpleby, A. Margot; Green, Daniel J.; Cable, N. Timothy; Jones, Helen; Cuthbertson, Daniel J. (American Physiological Society, 2014-11-01)Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular disease (CVD). Endothelial dysfunction is an early manifestation of atherosclerosis and an important prognostic marker for future ...
Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors Green, Daniel; Eijsvogels, Thijs; Bouta, Yvette; Malorana, Andrew; Naylor, Louise; Scholten, Ralph; Spaanderman, Marc; Pugh, Christopher J. A.; Sprung, Victoria; Schreuder, Tim; Jones, Helen; Cable, Tim; Hopman, Marla; Thijssen, Dick (American Physiological Society, 2014-06-19)The objectives of our study were to examine1) the proportion of responders and nonresponders to exercise training in terms of vascular function;2) a priori factors related to exercise training induced changes in conduit ...