Micro-management: curbing chronic wound infection
MetadataDangos cofnod eitem llawn
Chronic wounds, including pressure ulcers, foot ulcers and venous leg ulcers have a detrimental impact on the health and well-being of an estimated 2% of people in the UK. Chronic wounds are normally colonised by bacteria and in some instances bacterial load increases sufficiently for infection to ensue. Once a chronic wound becomes infected it is difficult to resolve and a combination of continuous inflammation and bacterial proliferation makes these wounds difficult to manage. A state of prolonged inflammation can occur as a result of impaired homeostatic pathways which are exacerbated by bacterial growth. Chronic, infected wounds can persist for many months or even years, sometimes requiring surgical intervention in the form of regular debridement or amputation when other strategies such as antimicrobial treatments fail. The complex relationships between both oral microbiota and the host have been extensively characterised, including the shift from health to disease, and has allowed for the development of numerous control strategies. This knowledge combined with contemporary studies of chronic infected wounds can be used to develop an understanding of the relationship between the host and microorganism in the chronic wound environment. Such information has the potential to inform wound management including strategies to control infection and promote wound healing.
Molecular Oral Microbiology
Withycombe, C., Purdy, K.J. and Maddocks, S.E. (2016) 'Micro‐management: curbing chronic wound infection', Molecular Oral Microbiology.
Dynodwr Gwrthrych Digidol (DOI)http://dx.doi.org/10.1111/omi.12174
This article was published in Molecular Oral Microbiology on 12 August 2016 (accepted manuscript online), available at http://dx.doi.org/10.1111/omi.12174
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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Okhiria, Olusola Adeola (University of WalesCardiff School of Health Sciences, 2010)Biofilms have long been implicated in persistent infections and have recently been associated with chronic wounds. The role of bacteria in wounds is not yet fully understood and their ability to form biofilm is yet to be ...
Ngo Maleguel Epse Kamdem, Jaqueline (University of WalesCardiff School of Health Sciences, 2010)There is a growing recognition that biofilms are the principal cause of chronicity or persistence in infections. Biofilms have been implicated in chronic wounds as a cause of delayed healing. However, only few wound ...
Alhinai, Asma (University of Wales Institute Cardiff, 2012)Wound healing is a complex process with many probable factors that can delay healing; wound infection, especially biofilm infection, is one of these delaying factors. The wound is colonized by bacteria and the bacteria ...