The antibacterial activity of date syrup polyphenols against S. aureus and E. coli
MetadataShow full item record
Plant-derived products such as date syrup have demonstrated antibacterial activity and can inhibit bacteria through numerous different mechanisms, which may be attributed to bioactive compounds including plant-derived phenolic molecules. Date syrup is rich in polyphenols and this study hypothesized that date syrup polyphenols demonstrate inherent antimicrobial activity, which cause oxidative damage. This investigation revealed that date syrup has a high content of total polyphenols (605 mg/100g), and is rich in tannins (357 mg/100g), flavonoids (40.5 mg/100g) and flavanols (31.7 mg/100g) that are known potent antioxidants. Furthermore, date syrup, and polyphenols extracted from date syrup, the most abundant bioactive constituent of date syrup are bacteriostatic to both Gram positive and Gram negative Escherichia coli and Staphylococcus aureus respectively. It has further been shown that the extracted polyphenols independently suppress the growth of bacteria at minimum inhibitory concentration (MIC) of 30 mg/mL and 20 mg/mL for E. coli and S. aureus, and have observed that date syrup behaves as a prooxidant by generating hydrogen peroxide that mediates bacterial growth inhibition as a result of oxidative stress. At sub-lethal MIC concentrations date syrup demonstrated antioxidative activity by reducing hydrogen peroxide, and at lethal concentrations date syrup demonstrated prooxidant activity that inhibited the growth of E. coli and S. aureus. The high sugar content naturally present in date syrup did not significantly contribute to this effect. These findings highlight that date syrup’s antimicrobial activity is mediated through hydrogen peroxide generation in inducing oxidative stress in bacteria.
Frontiers in Microbiology;
Taleb, H., Maddocks, S.E., Morris, R.K. and Kanekanian, A.D. (2016) 'The antibacterial activity of date syrup polyphenols against S. aureus and E. coli', Frontiers in Microbiology 7,198. doi: 10.3389/fmicb.2016.00198
This article was published in Frontiers in Microbiology on 26 February 2016, availble open access online at http://dx.doi.org/10.3389/fmicb.2016.00198
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Showing items related by title, author, subject and abstract.
Date syrup derived polyphenols attenuate angiogenic responses and exhibits anti-inflammatory activity mediated by VEGF and COX-2 expression in endothelial cells Taleb, Hajer; Morris, Keith; Withycombe, Cathryn; Maddocks, Sarah; Kanekanian, Ara (Science Direct, 2016-02-22)Bioactive components such as polyphenols, present in many plants, are purported to have anti-inflammatory and antiangiogenic properties. Date syrup, produced from date fruit of the date palm tree, has traditionally been ...
Chemical characterisation and the anti-inflammatory, anti-angiogenic and antibacterial properties of date fruit (Phoenix dactylifera L.) Taleb, Hajer; Maddocks, Sarah; Morris, Keith; Kanekanian, Ara (Elsevier, 2016-10-10)Ethnopharmacological relevance: Date fruit, Phoenix dactylifera L. has traditionally been used as a medicine in many cultures for the treatment of a range of ailments such as stomach and intestinal disorders, fever, oedema, ...
French, V.M.; Cooper, Rose; Molan, P.C. (Oxford Journals, 2005-07-01)Objectives: Development of antibiotic-resistant strains of coagulase-negative staphylococci has complicated the management of infections associated with the use of invasive medical devices, and innovative treatment and ...