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dc.contributor.authorFoster, Glen
dc.contributor.authorAinslie, Philip
dc.contributor.authorStembridge, Mike
dc.contributor.authorDay, Trevor A.
dc.contributor.authorBakker, Akke
dc.contributor.authorLucas, Samuel J.E.
dc.contributor.authorLewis, Nia C. S.
dc.contributor.authorMacleod, David B.
dc.contributor.authorLovering, Andrew T.
dc.date.accessioned2016-11-25T15:34:40Z
dc.date.available2016-11-25T15:34:40Z
dc.date.issued2014-03-15
dc.identifier.citationFoster, G.E., Ainslie, P.N., Stembridge, M., Day, T.A., Bakker, A., Lucas, S.J., Lewis, N., MacLeod, D.B. and Lovering, A.T. (2014) 'Resting pulmonary haemodynamics and shunting: a comparison of sea‐level inhabitants to high altitude Sherpas', The Journal of Physiology, 592 (6), pp.1397-1409en_US
dc.identifier.issn0022-3751
dc.identifier.urihttp://hdl.handle.net/10369/8195
dc.descriptionThis article was published in The Journal of Physiology on 12 February 2014 (online), available free at http://dx.doi.org/10.1113/jphysiol.2013.266593en_US
dc.description.abstractThe incidence of blood flow through intracardiac shunt and intrapulmonary arteriovenous anastomoses (IPAVA) may differ between Sherpas permanently residing at high altitude (HA) and sea-level (SL) inhabitants as a result of evolutionary pressure to improve gas exchange and/or resting pulmonary haemodynamics. To test this hypothesis we compared sea-level inhabitants at SL (SL-SL; n = 17), during acute isocapnic hypoxia (SL-HX; n = 7) and following 3 weeks at 5050 m (SL-HA; n = 8 non-PFO subjects) to Sherpas at 5050 m (n = 14). inline image, heart rate, pulmonary artery systolic pressure (PASP) and cardiac index (Qi) were measured during 5 min of room air breathing at SL and HA, during 20 min of isocapnic hypoxia (SL-HX; inline image = 47 mmHg) and during 5 min of hyperoxia (inline image = 1.0; Sherpas only). Intracardiac shunt and IPAVA blood flow was evaluated by agitated saline contrast echocardiography. Although PASP was similar between groups at HA (Sherpas: 30.0 ± 6.0 mmHg; SL-HA: 32.7 ± 4.2 mmHg; P = 0.27), it was greater than SL-SL (19.4 ± 2.1 mmHg; P < 0.001). The proportion of subjects with intracardiac shunt was similar between groups (SL-SL: 41%; Sherpas: 50%). In the remaining subjects, IPAVA blood flow was found in 100% of subjects during acute isocapnic hypoxia at SL, but in only 4 of 7 Sherpas and 1 of 8 SL-HA subjects at rest. In conclusion, differences in resting pulmonary vascular regulation, intracardiac shunt and IPAVA blood flow do not appear to account for any adaptation to HA in Sherpas. Despite elevated pulmonary pressures and profound hypoxaemia, IPAVA blood flow in all subjects at HA was lower than expected compared to acute normobaric hypoxia.en_US
dc.description.sponsorshipThis study was carried out within the framework of the Ev-K2-CNR Project in collaboration with Nepal Academy of Science and Technology as foreseen in the Memorandum of Understanding between Nepal and Italy, and thanks to a contribution from the Italian National Research Council.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesThe Journal of Physiology;
dc.rightsNon-Commercial
dc.subjectHigh altitudeen_US
dc.subjectpulmonary hypoxic vasoconstrictionen_US
dc.subjectshunten_US
dc.titleResting pulmonary haemodynamics and shunting: a comparison of sea-level inhabitants to high altitude Sherpasen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1113/jphysiol.2013.266593
dcterms.dateAccepted2013-12-24
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2016-11-25
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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