High-intensity interval training versus moderate-intensity steady-state training in UK cardiac rehabilitation programmes (HIIT or MISS UK): study protocol for a multicentre randomised controlled trial and economic evaluation

View/ open
Author
McGregor, Gordon
Nichols, Simon
Hamborg, Thomas
Bryning, Lucy
Tudor-Edwards, Rhiannon
Markland, David
Mercer, Jenny
Birkett, Stefan
Ennis, Stuart
Powell, Richard
Begg, Brian
Haykowsky, Mark J
Banerjee, Prithwish
Ingle, Lee
Shave, Rob
Backx, Karianne
Date
2016-11-16Acceptance date
2016-10-05
Type
Article
Publisher
BMJ Publishing Group
ISSN
2044-6055
Metadata
Show full item recordAbstract
Introduction
Current international guidelines for cardiac rehabilitation (CR) advocate moderate-intensity exercise training (MISS, moderate-intensity steady state). This recommendation predates significant advances in medical therapy for coronary heart disease (CHD) and may not be the most appropriate strategy for the ‘modern’ patient with CHD. High-intensity interval training (HIIT) appears to be a safe and effective alternative, resulting in greater improvements in peak oxygen uptake (VO2 peak). To date, HIIT trials have predominantly been proof-of-concept studies in the laboratory setting and conducted outside the UK. The purpose of this multicentre randomised controlled trial is to compare the effects of HIIT and MISS training in patients with CHD attending UK CR programmes.
Methods and analysis
This pragmatic study will randomly allocate 510 patients with CHD to 8 weeks of twice weekly HIIT or MISS training at 3 centres in the UK. HIIT will consist of 10 high-intensity (85–90% peak power output (PPO)) and 10 low-intensity (20–25% PPO) intervals, each lasting 1 min. MISS training will follow usual care recommendations, adhering to currently accepted UK guidelines (ie, >20 min continuous exercise at 40–70% heart rate reserve). Outcome measures will be assessed at baseline, 8 weeks and 12 months. The primary outcome for the trial will be change in VO2 peak as determined by maximal cardiopulmonary exercise testing. Secondary measures will assess physiological, psychosocial and economic outcomes.
Ethics and dissemination
The study protocol V.1.0, dated 1 February 2016, was approved by the NHS Health Research Authority, East Midlands—Leicester South Research Ethics Committee (16/EM/0079). Recruitment will start in August 2016 and will be completed in June 2018. Results will be published in peer-reviewed journals, presented at national and international scientific meetings and are expected to inform future national guidelines for exercise training in UK CR.
Journal/conference proceeding
BMJ Open;
Citation
McGregor, G., Nichols, S., Hamborg, T., Bryning5, , L., Tudor-Edwards, R., Markland, D., Mercer, J., Birkett, S., Ennis, S., Powell, R., Begg, B., Haykowsky, M.J., Banerjee, P., Ingle, L., Shave, R., Backx, K. (2016) 'High-intensity interval training versus moderate-intensity steady-state training in UK cardiac rehabilitation programmes (HIIT or MISS UK): study protocol for a multicentre randomised controlled trial and economic evaluation', BMJ Open, 6; 11, e012843.
Description
This article was published in BMJ open on 16 November 2016 (online), available open access at http://dx.doi.org/10.1136/bmjopen-2016-012843
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Collections
- Sport Research Groups [789]
- Health and Risk Management [200]
Related items
Showing items related by title, author, subject and abstract.
-
Does high intensity interval exercise promote post-exercise hypotension?
Lane, Sophie (Cardiff Metropolitan University, 2015)Introduction: High blood pressure has been identified to largely contribute to cardiovascular disease. Regular exercise has been prescribed by medical organisations as a strategy to treat and prevent high blood pressure. ... -
The Influence of High Intensity Exercise on Post-Exercise Hypotension
Incledon, Zavia (Cardiff Metropolitan University, 2014)Background. Elevated blood pressure is one of the most significant risk factors for cardiovascular disease. Post-exercise hypotension is the phenomenon by which there is a prolonged reduction in blood pressure in the ... -
A Comparison of Resting Blood Pressure Differences Between Those Trained in Different Exercise Modalities: Is Resistance Training as Beneficial as Aerobic Training to Cardiovascular Health?
Davies, Henry (University of Wales Institute Cardiff, 2012)Resting blood pressure is a strong predictor of cardiovascular disease, with direct implications to cardiovascular health. Exercise is a powerful non-pharmacological treatment for hypertension. Aerobic forms of exercise ...