• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Cardiovascular Health and Ageing
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Cardiovascular Health and Ageing
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Nitrate pharmacokinetics: taking note of the difference

Thumbnail
Author
James, Philip
Willis, Gareth R.
Allen, Jason D.
Winyard, Paul G.
Jones, Andrew M.
Date
2015-08-01
Acceptance date
2015-04-22
Type
Article
Publisher
Elsevier
Metadata
Show full item record
Abstract
It is now recognised that administration of oral nitrate (NO3 - ), in its various forms, increases the level of nitric oxide (NO) metabolites in the circulation of humans. Its application to modulate physiology and alleviate cardiovascular dysfunction in some patients is now recorded and shows particular promise in hypertension, in modifying platelet activation/aggregation, and in conditions where tissue ischemia prevails. The potential of oral NO3 - to modify exercise/performance via elevation of plasma nitrite concentration ([NO2 - ]) has been applied across a range of human test systems. Herein we discuss how the choice of NO3 - source, route of administration and resulting pharmacokinetics might influence the outcome of physiological measures and potentially contribute to discrepancies in performance trials. There are but a few examples of detailed pharmacokinetic data on which the majority of researchers base their test protocols in different cohorts/settings. We compare and contrast the results of key publications with the aim of highlighting a consensus of our current understanding and critical considerations for those entering the field.
Journal/conference proceeding
Nitric Oxide;
Citation
James, P.E., Willis, G.R., Allen, J.D., Winyard, P.G. and Jones, A.M. (2015) 'Nitrate pharmacokinetics: Taking note of the difference', Nitric Oxide, 48, pp.44-50.
URI
https://ore.exeter.ac.uk/repository/bitstream/handle/10871/17198/JamesNitricOxide2015%201-s2.0-S1089860315002086-main.pdf?sequence=1&isAllowed=y
http://hdl.handle.net/10369/8269
DOI
10.1016/j.niox.2015.04.006
Description
This article was published in Nitric Oxide on 29 April 2015 (online), available at http://dx.doi.org/10.1016/j.niox.2015.04.006
Collections
  • Cardiovascular Health and Ageing [101]

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator