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dc.contributor.authorJames, Philip
dc.contributor.authorWillis, Gareth R.
dc.contributor.authorAllen, Jason D.
dc.contributor.authorWinyard, Paul G.
dc.contributor.authorJones, Andrew M.
dc.date.accessioned2016-12-15T14:51:06Z
dc.date.available2016-12-15T14:51:06Z
dc.date.issued2015-08-01
dc.identifier.citationJames, P.E., Willis, G.R., Allen, J.D., Winyard, P.G. and Jones, A.M. (2015) 'Nitrate pharmacokinetics: Taking note of the difference', Nitric Oxide, 48, pp.44-50.en_US
dc.identifier.urihttps://ore.exeter.ac.uk/repository/bitstream/handle/10871/17198/JamesNitricOxide2015%201-s2.0-S1089860315002086-main.pdf?sequence=1&isAllowed=y
dc.identifier.urihttp://hdl.handle.net/10369/8269
dc.descriptionThis article was published in Nitric Oxide on 29 April 2015 (online), available at http://dx.doi.org/10.1016/j.niox.2015.04.006en_US
dc.description.abstractIt is now recognised that administration of oral nitrate (NO3 - ), in its various forms, increases the level of nitric oxide (NO) metabolites in the circulation of humans. Its application to modulate physiology and alleviate cardiovascular dysfunction in some patients is now recorded and shows particular promise in hypertension, in modifying platelet activation/aggregation, and in conditions where tissue ischemia prevails. The potential of oral NO3 - to modify exercise/performance via elevation of plasma nitrite concentration ([NO2 - ]) has been applied across a range of human test systems. Herein we discuss how the choice of NO3 - source, route of administration and resulting pharmacokinetics might influence the outcome of physiological measures and potentially contribute to discrepancies in performance trials. There are but a few examples of detailed pharmacokinetic data on which the majority of researchers base their test protocols in different cohorts/settings. We compare and contrast the results of key publications with the aim of highlighting a consensus of our current understanding and critical considerations for those entering the field.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesNitric Oxide;
dc.subjectNitriteen_US
dc.subjectNitrateen_US
dc.subjectPharmacokineticsen_US
dc.subjectExerciseen_US
dc.titleNitrate pharmacokinetics: taking note of the differenceen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.niox.2015.04.006
dcterms.dateAccepted2015-04-22
rioxxterms.versionNAen_US


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