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dc.contributor.authorKearney, Maria
dc.contributor.authorGallop-Evans, Eve
dc.contributor.authorCockcroft, John R.
dc.contributor.authorStöhr, Eric J.
dc.contributor.authorLee, Eveline
dc.contributor.authorBackx, Karianne
dc.contributor.authorHaykowski, Mark
dc.contributor.authorYousef, Zaheer
dc.contributor.authorShave, Rob
dc.date.accessioned2017-01-04T09:34:20Z
dc.date.available2017-01-04T09:34:20Z
dc.date.issued2016-12-30
dc.identifier.citationKearney, M., Gallop-Evans, E., Cockcroft, J., Stohr, E., Lee, E., Backx, K., Haykowsky, M., Yousef, Z. and Shave, R. (2016) 'Cardiac dysfunction in cancer survivors unmasked during exercise' European Journal of Clinical Investigation (online).en_US
dc.identifier.issn0014-2972
dc.identifier.urihttp://hdl.handle.net/10369/8275
dc.descriptionThis article was published in European Journal of Clinical Investigation on 30 December 2016 (online), available at http://dx.doi.org/10.1111/eci.12720en_US
dc.description.abstractIntroduction: The cardiac dysfunction associated with anthracycline-based chemotherapy cancer treatment can exist sub-clinically for decades before overt presentation. Stress echocardiography, the measurement of left ventricular (LV) deformation and arterial haemodynamic evaluation have separately been used to identify sub-clinical cardiovascular (CV) dysfunction in several patient groups including those with hypertension and diabetes. The purpose of the present cross-sectional study was to determine whether the combination of these techniques could be used to improve the characterisation of sub-clinical CV dysfunction in long-term cancer survivors previously treated with anthracyclines. Materials and methods: Thirteen long-term cancer survivors (36±10 years) with prior anthracycline exposure (11±8 years post-treatment) and 13 age-matched controls were recruited. Left ventricular structure, function and deformation were assessed using echocardiography. Augmentation index was used to quantify arterial haemodynamic load and was measured using applanation tonometry. Measurements were taken at rest and during two stages of low-intensity incremental cycling.Results: At rest, both groups had comparable global LV systolic, diastolic and arterial function (all P>0.05), however longitudinal deformation was significantly lower in cancer survivors (-18±2 v -20±2, P<0.05). During exercise this difference between groups persisted and further differences were uncovered with significantly lower apical circumferential deformation in the cancer survivors (-24±5 v -29±5, -29±5 v 35±8 for first and second stage of exercise respectively, both P<0.05). Conclusion: In contrast to resting echocardiography the measurement of LV deformation at rest and during exercise provides a more comprehensive characterisation of sub-clinical LV dysfunction. Larger studies are required to determine the clinical relevance of these preliminary findings.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesEuropean Journal of Clinical Investigation;
dc.subjectAnthracyclinesen_US
dc.subjectExercise echocardiographyen_US
dc.subjectCardiac deformationen_US
dc.subjectArterial haemodynamicsen_US
dc.titleCardiac dysfunction in cancer survivors unmasked during exerciseen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1111/eci.12720
dcterms.dateAccepted2016-12-28
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2017-01-04
rioxxterms.freetoread.startdate2017-12-30
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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